5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
- CAS No.
- 137275-80-0
- Chemical Name:
- 5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
- Synonyms
- MCI242;MN-305;MCI-242;Osemozotan HCl;Osemozotan hydrochloride;5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
- CBNumber:
- CB03192333
- Molecular Formula:
- C19H22ClNO5
- Molecular Weight:
- 379.83468
- MDL Number:
- MFCD00905894
- MOL File:
- 137275-80-0.mol
| Product description | Number | Pack Size | Price |
| 5-(3-((2S)-(1,4-BENZODIOXAN-2-YLMETHYL)AMINO)PROPOXY)-1,3-BENZODIOXOL HYDROCHLORIDE 95.00% | API0009613 | 5MG | $500.3 |
| FDA UNII | F0WKFYPQL8 |
|---|
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0009613 | 5-(3-((2S)-(1,4-BENZODIOXAN-2-YLMETHYL)AMINO)PROPOXY)-1,3-BENZODIOXOL HYDROCHLORIDE 95.00% | 137275-80-0 | 5MG | $500.3 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| API0009613 | 5MG | $500.3 | Buy |
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride Chemical Properties,Uses,Production
Uses
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].
in vivo
Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1]. Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2].
| Animal Model: | Female CD-1 mice with picrotoxin-induced decrease in female preference[1] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment |
| Result: | Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone. |
| Animal Model: | ICR mice with MAMP injection[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; 1 mg/kg; once |
| Result: | Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells. |
References
[1] Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. DOI:10.1111/bph.13692
[2] Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. DOI:10.1248/bpb.32.728
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Shanghai Anhua Biotechnology Co., Ltd. | 021-61263375 18168859245 | China | 5958 | 58 | |
| Wuxi maimo topp biotechnology co., LTD | 13771048682 13771048682 | linda-fu@mimotopes.cn | China | 5796 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
View Lastest Price from 5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-05 | Osemozotan HCl
137275-80-0
|
US $373.00-1220.00 / mg | 99.63% | 10g | TargetMol Chemicals Inc. |
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- Osemozotan HCl
137275-80-0
- US $373.00-1220.00 / mg
- 99.63%
- TargetMol Chemicals Inc.
