Fenmetozole (Tosylate)
- CAS No.
- 83474-08-2
- Chemical Name:
- Fenmetozole (Tosylate)
- Synonyms
- Fenmetozole (Tosylate)
- CBNumber:
- CB03339655
- Molecular Formula:
- C17H18Cl2N2O4S
- Molecular Weight:
- 417.30682
- MDL Number:
- MFCD31544467
- MOL File:
- 83474-08-2.mol
Fenmetozole (Tosylate) Chemical Properties,Uses,Production
Uses
Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant agent.
in vivo
In mice, fenmetozole antagonizes both the ethanol induced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg. Moreover, fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue. Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding. Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats. Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content[1]. Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats[2].
IC 50
α adrenergic receptor
References
[1] Frye GD, et al. An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function. Psychopharmacology (Berl). 1980;69(2):149-55. DOI:10.1007/BF00427641
[2] Vogel RA, et al. Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex. Alcohol Clin Exp Res. 1981 Summer;5(3):386-92. DOI:10.1111/j.1530-0277.1981.tb04921.x
[3] Stillings MR, et al. Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Sep;29(9):1780-3. DOI:10.1021/jm00159a037
Fenmetozole (Tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
Fenmetozole (Tosylate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19964 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
View Lastest Price from Fenmetozole (Tosylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-04 | Fenmetozole Tosylate
83474-08-2
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-07-21 | Fenmetozole Tosylate
83474-08-2
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Fenmetozole Tosylate
83474-08-2
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.
-
- Fenmetozole Tosylate
83474-08-2
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.
