3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
- CAS No.
- 1005-24-9
- Chemical Name:
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
- Synonyms
- 1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;nicotinamidemethochloride;nipecotamidemethochloride;Nicotinamide Impurity 127;nicotinamidemethylchloride;NICOTINAMIDE CHLOROMETHYLATE;n-methylnicotinamidechloride
- CBNumber:
- CB0431956
- Molecular Formula:
- C7H9ClN2O
- Molecular Weight:
- 172.61
- MDL Number:
- MFCD00060042
- MOL File:
- 1005-24-9.mol
- MSDS File:
- SDS
| Melting point | 207-209℃ (water acetone ) |
|---|---|
| storage temp. | room temp |
| solubility | H2O: soluble15mg/mL, clear |
| form | crystalline |
| color | white |
| Water Solubility | almost transparency |
| Merck | 14,9693 |
| CAS DataBase Reference | 1005-24-9(CAS DataBase Reference) |
| FDA UNII | L54XNJ1D5G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU1925000 | |||||||||
| HS Code | 2933.39.9200 | |||||||||
| NFPA 704 |
|
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0704 | 1-Methylnicotinamide chloride ≥98% (HPLC) | 1005-24-9 | 10mg | $44.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | M4627 | 1-Methylnicotinamide chloride analytical standard | 1005-24-9 | 1g | $180 | 2024-03-01 | Buy |
| TCI Chemical | M0375 | 3-Carbamyl-1-methylpyridinium Chloride >98.0%(HPLC)(T) | 1005-24-9 | 5g | $239 | 2024-03-01 | Buy |
| TCI Chemical | M0375 | 3-Carbamyl-1-methylpyridinium Chloride >98.0%(HPLC)(T) | 1005-24-9 | 25g | $695 | 2024-03-01 | Buy |
| Cayman Chemical | 16604 | 1-Methylnicotinamide (chloride) ≥95% | 1005-24-9 | 100mg | $32 | 2024-03-01 | Buy |
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Uses,Production
Description
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Uses
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Uses
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
General Description
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
Purification Methods
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52861 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co