SM16
- CAS No.
- 614749-78-9
- Chemical Name:
- SM16
- Synonyms
- SM16;CS-2835;SM 16, 10 mM in DMSO;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
- CBNumber:
- CB04656566
- Molecular Formula:
- C25H26N4O3
- Molecular Weight:
- 430.5
- MDL Number:
- MOL File:
- 614749-78-9.mol
| Product description | Number | Pack Size | Price |
| SM16 ≥98%(HPLC) | 6245 | 10 | $300 |
| SM16 99.96% | CS-0042167 | 50mg | $550 |
| SM16 99.96% | CS-0042167 | 10mg | $190 |
| SM16 99.96% | CS-0042167 | 5mg | $110 |
| SM16 99.96% | CS-0042167 | 100mg | $950 |
| More product size | |||
SM16 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6245 | SM16 ≥98%(HPLC) | 614749-78-9 | 10 | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0042167 | SM16 99.96% | 614749-78-9 | 50mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0042167 | SM16 99.96% | 614749-78-9 | 10mg | $190 | 2021-12-16 | Buy |
| ChemScene | CS-0042167 | SM16 99.96% | 614749-78-9 | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0042167 | SM16 99.96% | 614749-78-9 | 100mg | $950 | 2021-12-16 | Buy |
SM16 Chemical Properties,Uses,Production
Uses
SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
Biological Activity
SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.
in vivo
SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.
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target
Ki: ALK5 (10 nM), ALK4 (1.5 nM)
storage
Store at -20°C
References
[1] Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 Mar 1;67(5):2351-9. DOI:10.1158/0008-5472.CAN-06-2389
[2] Fu K, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. DOI:10.1161/ATVBAHA.107.158030
[3] Engebretsen KV, et al. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. J Mol Cell Cardiol. 2014 Nov;76:148-57. DOI:10.1016/j.yjmcc.2014.08.008
SM16 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185; | sales-cpd@caerulumpharma.com | China | 3505 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7778 | 56 |
