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SM16

SM16 structure

CAS No.: 614749-78-9

Chemical Name:: SM16

Synonyms: SM16;CS-2835;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-

CBNumber:: CB04656566

Molecular Formula:: C25H26N4O3

Molecular Weight:: 430.5

MDL Number:

MOL File:: 614749-78-9.mol

Last updated:2023-06-30 15:45:59

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SM16 Properties

Boiling point	691.3±55.0 °C(Predicted)
Density	1.354±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM)
form	A solid
pka	11.23±0.10(Predicted)

SM16 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	6245	SM16 ≥98%(HPLC)	614749-78-9	10	$300	2021-12-16	Buy
ChemScene	CS-0042167	SM16 99.96%	614749-78-9	50mg	$550	2021-12-16	Buy
ChemScene	CS-0042167	SM16 99.96%	614749-78-9	10mg	$190	2021-12-16	Buy
ChemScene	CS-0042167	SM16 99.96%	614749-78-9	5mg	$110	2021-12-16	Buy
ChemScene	CS-0042167	SM16 99.96%	614749-78-9	100mg	$950	2021-12-16	Buy

Product number	Packaging	Price	Buy
6245	10	$300	Buy
CS-0042167	50mg	$550	Buy
CS-0042167	10mg	$190	Buy
CS-0042167	5mg	$110	Buy
CS-0042167	100mg	$950	Buy

SM16 Chemical Properties,Uses,Production

Biological Activity

SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.

in vivo

SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.

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target

Ki: ALK5 (10 nM), ALK4 (1.5 nM)

storage

Store at -20°C

SM16 Preparation Products And Raw materials

Raw materials

Preparation Products

SM16 Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Shanghai Lollane Biological Technology Co.,Ltd.	55

4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide CS-2835 Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]- SM16 SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16 614749-78-9