ChemicalBook >> CAS DataBase List >>IITZ-01
IITZ-01
- CAS No.
- 1807988-47-1
- Chemical Name:
- IITZ-01
- Synonyms
- IITZ-01;CS-2857;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
- CBNumber:
- CB04668033
- Molecular Formula:
- C26H23FN8O
- Molecular Weight:
- 482.51
- MDL Number:
- MFCD31746904
- MOL File:
- 1807988-47-1.mol
Last updated:2023-05-18 11:31:17
IITZ-01 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0067546 | IITZ-01 99.80% | 1807988-47-1 | 5mg | $120 | 2021-12-16 | Buy |
| AK Scientific | 8048EL | 4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine | 1807988-47-1 | 5mg | $162 | 2021-12-16 | Buy |
| ChemScene | CS-0067546 | IITZ-01 99.80% | 1807988-47-1 | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0067546 | IITZ-01 99.80% | 1807988-47-1 | 25mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0067546 | IITZ-01 99.80% | 1807988-47-1 | 50mg | $680 | 2021-12-16 | Buy |
IITZ-01 Chemical Properties,Uses,Production
Biological Activity
IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.
in vivo
IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
| Animal Model: | MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn nu BALB/c female nude mice. |
| Dosage: | 45 mg/kg. |
| Administration: | Intraperitoneal every alternate day for 4 weeks. |
| Result: | Inhibited average breast tumor growth when compared with control from third day of treatment. |
target
| PI3Kγ 2.62 μM (IC 50 ) | Autophagy < /span> |
IITZ-01 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Shanghai Send Pharmaceutical Technology Co., Ltd. | 021-58088081 Q2816483246 | hailey@shsendpharm.com | China | 3132 | 55 |
IITZ-01
AUTOPHAGY INHIBITOR;IITZ 01;IITZ01
Autophagy inhibitor IITZ-01
AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01
CS-2857
1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K
1807988-47-1
C26H23FN8O
API