ATR Kinase Inhibitor II - Calbiochem
- CAS No.
- Chemical Name:
- ATR Kinase Inhibitor II - Calbiochem
- Synonyms
- ATR Kinase Inhibitor II - Calbiochem
- CBNumber:
- CB04816885
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
ATR Kinase Inhibitor II - Calbiochem price More Price(1)
ATR Kinase Inhibitor II - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12 nM; Ki = 6 nM) with excellent selectivity over ATM, DNA-PK (IC50 >8 μM) and in a 50-kinase panel (% inhibition at 2 μM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420 nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin (Cat. No. 232120) cytotoxicity against tumor cells over normal cells by ~7-fold at 620 nM.
ATR Kinase Inhibitor II - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
ATR Kinase Inhibitor II - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |
ATR Kinase Inhibitor II - Calbiochem