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DAMNACANTHAL

DAMNACANTHAL structure

CAS No.: 477-84-9

Chemical Name:: DAMNACANTHAL

Synonyms: DAMNACANTAL;DAMNACANTHAL;3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE;1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone;3-Hydroxy-1-Methoxy-2-anthraquinonecarboxaldehyde;1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde;3-hydroxy-9,10-diketo-1-methoxy-anthracene-2-carbaldehyde;9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthraldehyde

CBNumber:: CB0681393

Molecular Formula:: C16H10O5

Molecular Weight:: 282.25

MDL Number:: MFCD00674209

MOL File:: 477-84-9.mol

Last updated:2023-05-18 11:31:21

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DAMNACANTHAL Properties

Melting point	218～219℃
Boiling point	531.9±50.0 °C(Predicted)
Density	1.461±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 7 mg/ml)
pka	5.26±0.20(Predicted)
form	Pale orange solid.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII	WUC3CB63CD

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501

DAMNACANTHAL price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	251650	Damnacanthal - CAS 477-84-9 - Calbiochem	477-84-9	1mg	$272	2024-03-01	Buy
Tocris	1936	Damnacanthal ≥98%(HPLC)	477-84-9	1	$175	2021-12-16	Buy
TRC	D134800	Damnacanthal	477-84-9	5mg	$185	2021-12-16	Buy
Usbiological	255101	Damnacanthal	477-84-9	1mg	$432	2021-12-16	Buy
Usbiological	007491	Damnacanthal	477-84-9	5mg	$496	2021-12-16	Buy

Product number	Packaging	Price	Buy
251650	1mg	$272	Buy
1936	1	$175	Buy
D134800	5mg	$185	Buy
255101	1mg	$432	Buy
007491	5mg	$496	Buy

DAMNACANTHAL Chemical Properties,Uses,Production

Description

Damnacanthal (477-84-9) is a potent inhibitor of p56lck?tyrosine kinase activity (IC50?= 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn?and p60src?tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1?Mobilizes intracellular Ca2+?in dermal fibroblasts.2?Inhibits LIM-kinase, impairing cell migration and invasion.3?A potent inhibitor of angiogenesis.4?Inhibits mast cell activation.5

Uses

Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Damnacanthal is used in the treatment of inflammatory-related diseases.

Definition

ChEBI: 3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde is a monohydroxyanthraquinone and an aldehyde.

target

References

1) Faltynek?et al.?(1995),?Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry,?34?12404 2) Aoki?et al.?(2000),?Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol.,?387?119 3) Ohashi?et al.?(2014),?Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell,?25?828 4) Garcia-Vilas?et al.?(2017),?The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters,?385?1 5) Garcia-Vilas?et al.?(2015),?Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol.,?65?86

DAMNACANTHAL Preparation Products And Raw materials

Raw materials

Preparation Products

DAMNACANTHAL Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9651	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
BioBioPha Co., Ltd.	0871-65217109 13211707573;	y.liu@mail.biobiopha.com	China	5654	65
Synchem OHG	+49 5662 408730	info@synchem.de	Germany	4708	70

Supplier	Advantage
Shaanxi Pioneer Biotech Co., Ltd .	58
Hubei xin bonus chemical co. LTD	58
Finetech Industry Limited	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Chemsky (shanghai) International Co.,Ltd	60
BioBioPha Co., Ltd.	65
Synchem OHG	70

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DAMNACANTHAL DAMNACANTAL 1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone 1-Methoxy-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde 3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE 1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde 9,10-Dihydro-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarbaldehyde 3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde 3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde 3-hydroxy-9,10-diketo-1-methoxy-anthracene-2-carbaldehyde 3-Hydroxy-1-Methoxy-2-anthraquinonecarboxaldehyde 9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthracenecarboxaldehyde 9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthraldehyde 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde 2-Anthracenecarboxaldehyde,9,10-dihydro-3-hydroxy-1-methoxy-9,10-dioxo- 477-84-9