2-hydroxy-3-(o-tolyloxy)propyl carbamate
- CAS No.
- 533-06-2
- Chemical Name:
- 2-hydroxy-3-(o-tolyloxy)propyl carbamate
- Synonyms
- Tolseram;Mephenesin carbamate;2-hydroxy-3-(o-tolyloxy)propyl carbamate;[2-hydroxy-3-(2-methylphenoxy)propyl] carbamate;3-(2-Methylphenoxy)-1,2-propanediol 1-carbamate;1,2-Propanediol, 3-(2-methylphenoxy)-, 1-carbamate;carbamic acid [2-hydroxy-3-(2-methylphenoxy)propyl] ester
- CBNumber:
- CB0893974
- Molecular Formula:
- C11H15NO4
- Molecular Weight:
- 225.24
- MDL Number:
- MOL File:
- 533-06-2.mol
| Melting point | about 93°; mp 80-84° |
|---|---|
| Boiling point | 366.75°C (rough estimate) |
| Density | 1.2102 (rough estimate) |
| refractive index | 1.5080 (estimate) |
| FDA UNII | PAD6SXB23N |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mM/kg): 2.77 i.p.; 7.67 orally (Dresel, Slater) |
|---|
2-hydroxy-3-(o-tolyloxy)propyl carbamate Chemical Properties,Uses,Production
Originator
Tolseram,Squibb,US,1954
Definition
ChEBI: Mephenesin carbamate is an aromatic ether.
Manufacturing Process
A solution of 32 g (0.30 mol) phosgene in 200 ml benzene is added dropwise at 30°C to a stirred solution of 53.5 g (0.32 mol) 3-o-toloxy-1,2-propanediol in 400 ml benzene. The mixture is stirred for an hour after the addition is completed, and a solution of 39 g of dimethylaniline in 100 ml benzene is then added, and stirring continued for a half-hour. Ice water (about one-third volume) is then added, and the benzene layer formed is separated and stirred with 500 mi concentrated ammonia at 5°C for six hours. The precipitated solid (weighing about 55 g) is recovered and recrystallized from water. The product thus obtained in a yield of about 53 g is 3-(o-toloxy)-2-hydroxypropyl carbamate: it is a crystalline solid melting at about 93°C, and having a lower water-solubility and higher oil-solubility than 3-o-toloxy-1,2-propanediol.
Therapeutic Function
Muscle relaxant
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 3710, 1950 DOI: 10.1021/ja01164a107
2-hydroxy-3-(o-tolyloxy)propyl carbamate Preparation Products And Raw materials
2-hydroxy-3-(o-tolyloxy)propyl carbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 58 |