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ChemicalBook >> CAS DataBase List >>Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester

Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester

Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester Structure
Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester structure
CAS No.
2138441-25-3
Chemical Name:
Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester
Synonyms
tert-butyl (5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)carbamate;Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester
CBNumber:
CB110164881
Molecular Formula:
C23H31N3O5
Molecular Weight:
429.51
MDL Number:
MOL File:
2138441-25-3.mol
Last updated:2023-02-23 14:24:07
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Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester Properties

Boiling point 677.5±55.0 °C(Predicted)
Density 1.218±0.06 g/cm3(Predicted)
pka 10.74±0.40(Predicted)

Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester Chemical Properties,Uses,Production

Biological Activity

Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].

References

[1]. Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12. [2]. Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.

Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester Suppliers

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Carbamic acid, N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-, 1,1-dimethylethyl ester tert-butyl (5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)carbamate 2138441-25-3