CYCLOBENZAPRINE HCL
- CAS No.
- 303-53-7
- Chemical Name:
- CYCLOBENZAPRINE HCL
- Synonyms
- CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
- CBNumber:
- CB1116384
- Molecular Formula:
- C20H21N
- Molecular Weight:
- 275.39
- MDL Number:
- MFCD00867680
- MOL File:
- 303-53-7.mol
- MSDS File:
- SDS
| Boiling point | bp1 175-180° |
|---|---|
| Density | 0.9504 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| pka | pKa 8.47 (Uncertain) |
| BCS Class | 1 |
| FDA UNII | 69O5WQQ5TI |
| ATC code | M03BX08 |
| NIST Chemistry Reference | Cyclobenzaprine(303-53-7) |
CYCLOBENZAPRINE HCL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | KIT7835 | Cyclobenzaprine(1.0mg/mLinMethanol) | 303-53-7 | 5x1ml | $105 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009177 | CYCLOBENZAPRINE 95.00% | 303-53-7 | 5MG | $497.28 | 2021-12-16 | Buy |
| AHH | MT-49581 | Cyclobenzaprine 98% | 303-53-7 | 0.05g | $410 | 2021-12-16 | Buy |
CYCLOBENZAPRINE HCL Chemical Properties,Uses,Production
Description
Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.
Originator
Flexeril,Merck Sharp andDohme,US,1977
Uses
It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.
Uses
Relaxant (muscle).
Definition
ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.
Manufacturing Process
In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.
brand name
Flexeril (McNeil).
Therapeutic Function
Muscle relaxant
Synthesis
Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).
CYCLOBENZAPRINE HCL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +8617731987558 | xingjiu@xingjiubiotech.com | China | 990 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
Related articles
- Can Cyclobenzaprine be used when it expires?
- No, Cyclobenzaprine is a muscle relaxant used primarily for the short-term treatment of muscle spasms and certain other muscul....
- Mar 15，2024
View Lastest Price from CYCLOBENZAPRINE HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-27 | CYCLOBENZAPRINE HCL
303-53-7
|
US $15.00 / KG | 1KG | 99.9% | 500MT/month | XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | |
 |
2022-09-14 | Cyclobenzaprine
303-53-7
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2020-01-10 | CYCLOBENZAPRINE HCL
303-53-7
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- CYCLOBENZAPRINE HCL
303-53-7
- US $15.00 / KG
- 99.9%
- XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
-
- Cyclobenzaprine
303-53-7
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- CYCLOBENZAPRINE HCL
303-53-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co