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ChemicalBook >> CAS DataBase List >>Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Structure
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- structure
CAS No.
2839318-19-1
Chemical Name:
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-
Synonyms
dBRD4-BD1;Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-
CBNumber:
CB112280499
Molecular Formula:
C50H53F3N8O9
Molecular Weight:
967
MDL Number:
MOL File:
2839318-19-1.mol
Last updated:2025-10-28 16:00:23
Request For Quotation

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Properties

Density 1.41±0.1 g/cm3(Predicted)
pka 10.68±0.40(Predicted)
form Solid
color White to light yellow

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Chemical Properties,Uses,Production

Description

dBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.

Uses

dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].

References

[1] Divakaran A, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. DOI:10.1021/acsmedchemlett.2c00300

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5927 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29243 58
Shanghai Fine Biotech Co.，Ltd 18221172427 sale@fine-biotech.com China 2735 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Fine Biotech Co.，Ltd 58

View Lastest Price from Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
dBRD4-BD1 pictures 2025-10-27 dBRD4-BD1
2839318-19-1
 US $2780.00-2120.00 / mg 10g TargetMol Chemicals Inc.
  • dBRD4-BD1 pictures
  • dBRD4-BD1
    2839318-19-1
  • US $2780.00-2120.00 / mg
  • TargetMol Chemicals Inc.
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-[2-[2-[2-[4-[5-[2-[2-methyl-5-(1-methylethyl)phenoxy]-4-pyrimidinyl]-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-1-piperidinyl]ethoxy]ethoxy]ethyl]- dBRD4-BD1 2839318-19-1 C50H53F3N8O9