besipirdine
- CAS No.
- 130953-69-4
- Chemical Name:
- besipirdine
- Synonyms
- HP 749;besipirdine;Besipirdine HCl;Besipirdine hydrochloride;ZDFVWDHZXAGROF-UHFFFAOYSA-N;1H-Indol-1-amine, N-propyl-N-4-pyridinyl-, monohydrochloride
- CBNumber:
- CB11360704
- Molecular Formula:
- C16H17N3.ClH
- Molecular Weight:
- 287.792
- MDL Number:
- MOL File:
- 130953-69-4.mol
| Melting point | 212-214° |
|---|---|
| FDA UNII | 2541WG0P2F |
besipirdine Chemical Properties,Uses,Production
Originator
Besipirdine,Hoechst-Roussel
Uses
Alzheimer’s disease treatment (cognition enhancer).
Manufacturing Process
Part A: N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine maleate:
A solution of N-(4-pyridinyl)-1H-indol-1-amine (6 g) in 25 ml of
dimethylformamide was slowly added to an ice-cooled suspension of NaH (1.3
g of 60% NaH dispersion in mineral oil was washed with hexanes, the liquid
was decanted and the residual solid was dispersed in 5 ml of
dimethylformamide). After anion formation, a solution of 1-bromopropane (4
g) in 5 ml of dimethylformamide was added. After one hour of stirring at
ambient temperature, the reaction mixture was stirred with ice-water and
extracted with dichloromethane. The organic extract was washed with water
and saturated sodium chloride solution, was dried over anhydrous magnesium
sulfate, filtered and concentrated to 8 g of oil. This oil was purified by HPLC
(silica, ethyl acetate) and thereafter by column chromatography (alumina,
ether) to give 6.4 g oil. This oil was converted to the maleate salt and
recrystallized from methanol/ether to give 6.8 g of crystals, m.p. 115-116°C.
Part B: N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine hydrochloride:
N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine maleate was converted to the free
base by action of alcaline agent. Then the free base oil was converted to the
hydrochloride salt which was recrystallized from methanol; m.p. 212-214°C.
Therapeutic Function
Cognition activator
besipirdine Preparation Products And Raw materials
besipirdine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20621 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from besipirdine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-20 | Besipirdine hydrochloride
130953-69-4
|
US $195.00-692.00 / mg | 98.40% | 10g | TargetMol Chemicals Inc. |
-
- Besipirdine hydrochloride
130953-69-4
- US $195.00-692.00 / mg
- 98.40%
- TargetMol Chemicals Inc.