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Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy-

Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- structure

CAS No.: 3031466-56-2

Chemical Name:: Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy-

Synonyms: Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy-

CBNumber:: CB114686200

Molecular Formula:: C21H24ClN3O3

Molecular Weight:: 401.89

MDL Number:

MOL File:: 3031466-56-2.mol

Last updated:2025-04-18 09:51:37

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Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- Properties

Density	1.267±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	8.91±0.10(predicted)

Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- Chemical Properties,Uses,Production

Uses

MAO A/HDAC-IN-1 is a dual?inhibitor?of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research[1]. MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

MAO A/HDAC-IN-1 (compound 15) reduces tumor size, reduced MAO A activity in brain and tumor tissues, and prolonged the survival^[1].

IC 50

MAO-A

References

[1] Samir Mehndiratta, et al. N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment. J Med Chem. 2022 Feb 10;65(3):2208-2224. DOI:10.1021/acs.jmedchem.1c01726

Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	996	55

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55

Benzamide, 4-[[[3-chloro-4-[3-(methyl-2-propyn-1-ylamino)propoxy]phenyl]amino]methyl]-N-hydroxy- 3031466-56-2