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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione structure

CAS No.: 16233-51-5

Chemical Name:: 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

Synonyms: 102776;2,4-Dihydr;2-d]pyriMidine-2;2-chloro-4-Morpholinothieno;hieno[3,2-d]pyrimidine-2,4-diol;thieno[3,2-d]pyrimidine-2,4-diol;1H-Thieno[3,2-d]pyrimidine-2,4-dione;Thieno[3,2-d]pyriMidine-2,4-diol(8CI);1H-Thieno[3,2-d][1,3]oxazine-2,4-dione;Thieno[3,2-d]pyrimidine2,4(1H,3H)-dione

CBNumber:: CB11483285

Molecular Formula:: C6H4N2O2S

Molecular Weight:: 168.17

MDL Number:: MFCD09909655

MOL File:: 16233-51-5.mol

MSDS File:: SDS

Last updated:2026-05-27 23:07:54

Product description	Number	Pack Size	Price
Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione	166801	1g	$468
1H-Thieno[3,2-d]pyrimidine-2,4-dione	072299	1.00g	$116
1H-Thieno[3,2-d]pyrimidine-2,4-dione	072299	5.00g	$301
1H-Thieno[3,2-d]pyrimidine-2,4-dione	072299	10.00g	$429
1H-Thieno[3,2-d]pyrimidine-2,4-dione 98%	T3716	250mg	$17
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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Properties

Melting point	>300 °C
Density	1.517±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	10.40±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C6H4N2O2S/c9-5-4-3(1-2-11-4)7-6(10)8-5/h1-2H,(H2,7,8,9,10)
InChIKey	QAFVXBQPQCSSLI-UHFFFAOYSA-N
SMILES	C1(=O)NC(=O)C2SC=CC=2N1
CAS DataBase Reference	16233-51-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Risk Statements	20/21/22
Safety Statements	24/25-36/37
HS Code	29335990

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	166801	Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione	16233-51-5	1g	$468	2026-06-03	Buy
Matrix Scientific	072299	1H-Thieno[3,2-d]pyrimidine-2,4-dione	16233-51-5	1.00g	$116	2026-05-18	Buy
Matrix Scientific	072299	1H-Thieno[3,2-d]pyrimidine-2,4-dione	16233-51-5	5.00g	$301	2026-05-18	Buy
Matrix Scientific	072299	1H-Thieno[3,2-d]pyrimidine-2,4-dione	16233-51-5	10.00g	$429	2026-05-18	Buy
Synthonix	T3716	1H-Thieno[3,2-d]pyrimidine-2,4-dione 98%	16233-51-5	250mg	$17	2026-05-06	Buy

Product number	Packaging	Price	Buy
166801	1g	$468	Buy
072299	1.00g	$116	Buy
072299	5.00g	$301	Buy
072299	10.00g	$429	Buy
T3716	250mg	$17	Buy

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Chemical Properties,Uses,Production

Chemical Properties

Grey solid

Uses

1H-Thieno[3,4-d]pyrimidine-2,4-dione is an analog of thieno[3,4-d]pyrimidine and can serve as an inhibitor of dipeptidyl peptidase IV, PKD (serine/threonine kinases) as well as take part in the synthesis of antagonists of the humane adenosine A2B receptor.

Synthesis

22288-78-4

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

16233-51-5

The general procedure for the synthesis of thieno[3,2-d]pyrimidine-2,4-dione from methyl 3-amino-2-thiophenecarboxylate was as follows: to a mixed solution containing methyl 3-amino-2-thiophenecarboxylate (101) (100.0 g, 636.9 mmol, 1.0 eq.), acetic acid (705 mL), and water (600 mL) was added slowly over a period of 1 h. To a mixture containing methyl 3-aminothiophene-2-carboxylate (101) ( 154.8 g, 1.91 mol, 3.0 eq.) of an aqueous solution (326 mL). The reaction mixture was stirred at room temperature for 20 hours before being filtered and the filter cake was washed with deionized water (500 mL). The resulting solid was transferred to an appropriately sized reactor, 2M aqueous sodium hydroxide solution (1.65 L) was added and the slurry was stirred for 2 h. The formation of the target product, thieno[3,2-d]pyrimidine-2,4-dione, was confirmed by LCMS. Subsequently, the reaction mixture was cooled to 10 °C and the pH was adjusted to 5.0-6.0 by slow addition of 3M aqueous hydrochloric acid (1.29 L). The slurry was filtered, the solids were washed with deionized water (700 mL) and dried in a vacuum oven at 50 °C for 24 h. Compound 102 (100 g, 94% yield) was obtained as an off-white solid. lCMS (m/z): 169.1 [ M + H]+. 1H NMR (400MHz, DMSO-d6): δ 6.92 (d, J=5.2Hz, 1H), 8.04 (d, J=5.2Hz, 1H), 11.14 (s, 1H), 11.51 (s, 1H).

References

[1] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 25; 30
[2] Patent: WO2011/49332, 2011, A2. Location in patent: Page/Page column 16
[3] Patent: US2012/277424, 2012, A1. Location in patent: Page/Page column 7
[4] Journal of Chemical Research, Miniprint, 1993, # 2, p. 548 - 575
[5] Patent: CN103980287, 2016, B. Location in patent: Paragraph 0117; 0118; 0119

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

Potassium cyanate 3-AMINOTHIOPHENE-2-CARBOXAMIDE Methyl 3-amino-2-thiophenecarboxylate MFCD10689797 2-Mercaptothieno[3,2-d]pyrimidin-4(1H)one

Sodium cyanate Urea Acetic acid

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Preparation Products

7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione 7-Bromothieno[3,2-d]pyrimidin-2-amine 2,4-Dichlorothieno[3,2-d]pyrimidine

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Suppliers

Global( 178)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5746	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione 16233-51-5	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione 16233-51-5		1KG	98%	100KG	Career Henan Chemical Co

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
16233-51-5
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
16233-51-5
$0.00
98%
Career Henan Chemical Co

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Spectrum

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione(16233-51-5)¹HNMR

16233-51-5(1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione)Related Search:

THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE Thieno[2,3-b]pyridine (8CI,9CI) THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID thieno[3,2-c]pyridine Thieno[3,2-b]thiophene-2,5-dicarboxaldehyde

tert-butyl thiazol-5-ylcarbamate Thieno[2,3-b]pyridine-5-carboxylic acid Thiazole-4-carboxaldehyde Methyl 2-Thiazolecarboxylate Thiazole-5-carboxylic acid

THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Thieno[3,2-b]pyridine-6-carboxylic acid Thieno[3,2-b]thiophene METHYL THIOPHENE-2-CARBOXYLATE methyl thiazolo[4,5-b]pyridine-6-carboxylate

THIENO(3 2-B)PYRIDIN-7-OL Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester Thieno[3,2-b]pyridine, 3-amino- (6CI)

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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione hieno[3,2-d]pyrimidine-2,4-diol 1H-Thieno[3,2-d]pyrimidine-2,4-dione 2,4-Dihydroxythieno[3,2-d]pyrimidine ,97% 1H-Thieno[3,2-d][1,3]oxazine-2,4-dione thieno[3,2-d]pyrimidine-2,4-diol Thieno[3,2-d]pyrimidine2,4(1H,3H)-dione 2-chloro-4-Morpholinothieno 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione-2 2,4-Dihydroxythieno[3,2-d]pyrimidine Thieno[3,2-d]pyrimidine-2,4-diol 2-d]pyriMidine-2 1H,2H,3H,4H-thieno[3,2-d]pyriMidine-2,4-dione Thieno[3,2-d]pyriMidine-2,4-diol(8CI) 102776 2,4-Dihydroxythieno[3,2-D]Pyrimidine(WX619939) 2,4-Dihydr 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione ISO 9001：2015 REACH Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9CI, ACI) 2,4-Dihydroxythiopheno [3,2-D] pyrimidine 1,3-Dihydrothieno[3,2-d]pyrimidine-2,4-dione 16233-51-5 6233-51-5 API intermediates Heterocycles Heterocycle-Pyrimidine series