[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT
- CAS No.
- 195628-97-8
- Chemical Name:
- [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT
- Synonyms
- [DPRO5] CRF, HUMAN, RAT;[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT;SER-GLU-GLU-PRO-DPRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-MET-GLU-ILE-ILE-NH2: SEEP-DP-ISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2
- CBNumber:
- CB1189407
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01636198
- MOL File:
- Mol file
[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Chemical Properties,Uses,Production
Uses
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].
in vivo
[DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1].
| Animal Model: | Sprague-Dowley rats[1] |
| Dosage: | 0.01-1 μg |
| Administration: | Intracerebroventricular injection; single dose |
| Result: | Decreased the number of visits into the light box in the dark-light test. |
References
[1] Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian. PMID:17209454
[2] Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7. DOI:10.1016/s0006-8993(01)03160-2
[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Preparation Products And Raw materials
Raw materials
Preparation Products
[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Nanjing Peptide Biotech Ltd. | 025-025-025-58361106-805-805-805 15951641583 | zhao.xu@njpeptide.com | China | 9980 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4803 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7061 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6628 | 58 |
| Shanghai Toyang Biotechnology Co., LTD | 021-59555769 13524932310 | 1405894150@qq.com | China | 7982 | 58 |
| Taiyuan Bailihengkang Biotechnology Co., Ltd | 19135651983 19135651983 | 18611134419@163.com | China | 4416 | 58 |
| Phygene | 18059081430 | 2070812664@qq.com | China | 1232 | 58 |