tesofensine
- CAS No.
- 195875-84-4
- Chemical Name:
- tesofensine
- Synonyms
- Tesofensine-13C-d3;(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
- CBNumber:
- CB12498844
- Molecular Formula:
- C17H23Cl2NO
- Molecular Weight:
- 328.28
- MDL Number:
- MFCD25976398
- MOL File:
- 195875-84-4.mol
| Boiling point | 396.6±42.0 °C(Predicted) |
|---|---|
| Density | 1.161±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL |
| form | A solid |
| pka | 10.46±0.60(Predicted) |
| Stability | Hygroscopic |
| InChI | InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1 |
| InChIKey | VCVWXKKWDOJNIT-ZOMKSWQUSA-N |
| SMILES | [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=C(Cl)C(Cl)=C1)[C@H]2COCC |
| FDA UNII | BLH9UKX9V1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
tesofensine Chemical Properties,Uses,Production
Description
Tesofensine ((1R, 2R, 3S, 5S)-3-(3, 4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane)) is an inhibitor of neuronal reuptake of dopamine, noradrenaline, and serotonin. Tesofensine was developed for the treatment of Alzheimer's and Parkinson's disease but lacked efficacy. Meta-analysis revealed that tesofensine (0.125–1.0 mg, once daily; oral) produced dose-dependent weight loss, and 32% of obese patients had ≥ 5% weight loss following 14 wk of treatment. Weight loss was accompanied by hypophagia, suggesting an appetite suppressant action[2].
History
Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].
Uses
Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
References
[1] Dourish, C. J. Wilding and J. Halford. “Anti-obesity Drugs: From Animal Models to Clinical Efficacy.”Animal and Translational Models for CNS Drug Discovery 2008: 271-315.
[2] Vidya Narayanaswami, Linda P. Dwoskin. “Obesity: Current and potential pharmacotherapeutics and targets.” Pharmacology Therapeutics 170 (2017): Pages 116-147.
tesofensine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 73 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 274 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| SHANGHAI HOHANCE CHEMICAL CO.,LTD | 021-31115312 18217084087 | mary@hohance.com | China | 139 | 62 |
| Hubei wei shi reagent group ltd., company | 027-59101766 13125137661 | 2853877621@qq.com | China | 3771 | 58 |
View Lastest Price from tesofensine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-15 | tesofensine
195875-84-4
|
US $22.00 / Box | 1Box | 99% | 10000Box | Shanghai Getian Industrial Co., LTD | |
 |
2024-04-23 | Livagen
195875-84-4
|
US $149.00-143.00 / Box | 1Box | 99% | 66666 | Hebei Weimiao Import and Export Trade Co., Ltd. | |
 |
2023-12-18 | Tesofensine
195875-84-4
|
US $110.00-90.00 / kilogram | 1kilogram | 99% | 10 tons/per week | Henan Tengmao Chemical Technology Co. LTD |
-
- tesofensine
195875-84-4
- US $22.00 / Box
- 99%
- Shanghai Getian Industrial Co., LTD
-
- Livagen
195875-84-4
- US $149.00-143.00 / Box
- 99%
- Hebei Weimiao Import and Export Trade Co., Ltd.
-
- Tesofensine
195875-84-4
- US $110.00-90.00 / kilogram
- 99%
- Henan Tengmao Chemical Technology Co. LTD