(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
- CAS No.
- 848193-72-6
- Chemical Name:
- (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
- Synonyms
- CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-
- CBNumber:
- CB12676079
- Molecular Formula:
- C14H15ClN2O
- Molecular Weight:
- 262.73
- MDL Number:
- MFCD11045286
- MOL File:
- 848193-72-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301-H315-H319-H335 |
Precautionary statements | P261-P301+P310-P305+P351+P338 |
Hazard Codes | Xn |
Risk Statements | 36/37/38 |
Safety Statements | 26 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C8742 | CHIC-35 ≥97% (chiral, HPLC) | 848193-72-6 | 1mg | $188 | 2024-03-01 | Buy |
Sigma-Aldrich | 566325 | SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem | 848193-72-6 | 500μg | $216 | 2024-03-01 | Buy |
Sigma-Aldrich | C8742 | CHIC-35 ≥97% (chiral, HPLC) | 848193-72-6 | 5mg | $582 | 2024-03-01 | Buy |
American Custom Chemicals Corporation | INB0004657 | (6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00% | 848193-72-6 | 5MG | $498.64 | 2021-12-16 | Buy |
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Chemical Properties,Uses,Production
Definition
ChEBI: CHIC-35 is an organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is an aromatic compound, an organic heterotricyclic compound, an organochlorine compound and a primary carboxamide.
General Description
A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.
Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29802 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Aladdin Scientific | 58 |
Syntechem Co.,Ltd | 57 |
Sigma-Aldrich | 80 |
Shanghai Maclean Biochemical Technology Co., LTD | 58 |
TargetMol Chemicals Inc. | 58 |