2-Hydroxy Atorvastatin Calcium Salt
- CAS No.
- 265989-46-6
- Chemical Name:
- 2-Hydroxy Atorvastatin Calcium Salt
- Synonyms
- Atorvastatin Impurity K;2-Hydroxy Atorvastatin Sodium;2-Hydroxy Atorvastatin CalciuM Salt;inhibit,2-Hydroxy atorvastatin,2Hydroxy atorvastatin calcium salt,Drug Metabolite,Inhibitor,2 Hydroxy atorvastatin calcium salt;calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt;2-Hydroxy Atorvastatin Calcium SaltQ: What is 2-Hydroxy Atorvastatin Calcium Salt Q: What is the CAS Number of 2-Hydroxy Atorvastatin Calcium Salt Q: What is the storage condition of 2-Hydroxy Atorvastatin Calcium Salt Q: What are the applications of 2-Hydroxy Atorvastatin Calcium Salt;2-Hydroxy Atorvastatin D5 Calcium SaltQ: What is 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the CAS Number of 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the storage condition of 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What are the applications of 2-Hydroxy Atorvastatin D5 Calcium Salt
- CBNumber:
- CB12709452
- Molecular Formula:
- C33H37CaFN2O6
- Molecular Weight:
- 616.74
- MDL Number:
- MFCD08063637
- MOL File:
- 265989-46-6.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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2-Hydroxy Atorvastatin Calcium Salt price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 30974 | 2-hydroxy Atorvastatin (calcium salt) | 265989-46-6 | 1mg | $242 | 2024-03-01 | Buy |
Usbiological | 280154 | 2-Hydroxy atorvastatin calcium salt | 265989-46-6 | 5mg | $1204 | 2021-12-16 | Buy |
TRC | H828930 | 2-HydroxyAtorvastatinCalciumSalt | 265989-46-6 | 100mg | $4540 | 2021-12-16 | Buy |
TRC | H828930 | 2-HydroxyAtorvastatinCalciumSalt | 265989-46-6 | 1mg | $135 | 2021-12-16 | Buy |
ChemScene | CS-0100506 | 2-Hydroxyatorvastatincalciumsalt 97.68% | 265989-46-6 | 1mg | $150 | 2021-12-16 | Buy |
2-Hydroxy Atorvastatin Calcium Salt Chemical Properties,Uses,Production
Chemical Properties
White to Pale Yellow Solid
Uses
di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Biological Activity
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.
2-Hydroxy Atorvastatin Calcium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
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