ChemicalBook >> CAS DataBase List >>OTX 008
OTX 008
- CAS No.
- 286936-40-1
- Chemical Name:
- OTX 008
- Synonyms
- PTX 008;Calixarene 0118;OTX008 (Calixarene 0118;Calix[4]arene compound 0118;OTX008 (Synonyms: Calixarene 0118;PTX 008,OTX 008,Galectin,Calixarene0118,PTX-008,inhibit,OTX008,Calixarene-0118,OTX-008,Inhibitor;2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-
- CBNumber:
- CB13146348
- Molecular Formula:
- C52H72N8O8
- Molecular Weight:
- 937.18
- MDL Number:
- MFCD28396412
- MOL File:
- 286936-40-1.mol
Last updated:2023-05-21 10:59:17
| Boiling point | 1143.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.5 mg/ml |
| form | A crystalline solid |
| pka | 13.84±0.46(Predicted) |
| FDA UNII | 8JI63CFH5V |
OTX 008 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23130 | OTX008 ≥98% | 286936-40-1 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 23130 | OTX008 ≥98% | 286936-40-1 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 23130 | OTX008 ≥98% | 286936-40-1 | 5mg | $535 | 2024-03-01 | Buy |
| Cayman Chemical | 23130 | OTX008 ≥98% | 286936-40-1 | 10mg | $936 | 2024-03-01 | Buy |
| ChemScene | CS-0016572 | OTX008 99.36% | 286936-40-1 | 25mg | $590 | 2021-12-16 | Buy |
OTX 008 Chemical Properties,Uses,Production
Biological Activity
OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with antitumor activity.
in vivo
OTX008 inhibits growth of A2780-1A9 xenografts. OTX008 treatment is associated with down-regulation of Gal1 and Ki67 in treated tumours, as well as decreased microvessel density and VEGFR2 expression. Finally, combination studies show OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first.
target
| Target | Value |
| galectin-1 () |
OTX 008 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 36)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
OTX008 (Calixarene 0118
OTX008 (Synonyms: Calixarene 0118
Calix[4]arene compound 0118
Calixarene 0118
PTX 008
Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-
2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide)
PTX 008,OTX 008,Galectin,Calixarene0118,PTX-008,inhibit,OTX008,Calixarene-0118,OTX-008,Inhibitor
2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide)
286936-40-1
C52H72N8O8