INCB-047775
- CAS No.
- 1430056-54-4
- Chemical Name:
- INCB-047775
- Synonyms
- AKT-IN-6;INCB-047775;AKT IN 6,AKTIN6;AKT-IN-6, 10 mM in DMSO;(S)-5-(2-(1-amino-3-(3-fluorophenyl)propan-2-yl)-1-oxoisoindolin-5-yl)-1-methyl-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl-
- CBNumber:
- CB13168500
- Molecular Formula:
- C22H20FN5O
- Molecular Weight:
- 389.43
- MDL Number:
- MFCD30470660
- MOL File:
- 1430056-54-4.mol
| Product description | Number | Pack Size | Price |
| INCB-047775 | I499608 | 1mg | $45 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
INCB-047775 Chemical Properties,Uses,Production
Uses
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
Biological Activity
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].
IC 50
Akt1; Akt2; Akt3
References
[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1. [2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.
INCB-047775 Preparation Products And Raw materials
Raw materials
Preparation Products
INCB-047775 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Aikon International Limited | 025-58859352 18068836627 | dt3@aikonchem.com | China | 15493 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1810 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sales@pharmablock.com | China | 7268 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Shenzhen Zuoke Biotechnology Co., Ltd. | 13532174601 | CHINA | 109 | 58 |
