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Cyclopentanone, 2,5-bis(2-thienylmethylene)-

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Structure
Cyclopentanone, 2,5-bis(2-thienylmethylene)- structure
CAS No.
1087-07-6
Chemical Name:
Cyclopentanone, 2,5-bis(2-thienylmethylene)-
Synonyms
Cyclopentanone, 2,5-bis(2-thienylmethylene)-;PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
CBNumber:
CB13178361
Molecular Formula:
C15H12OS2
Molecular Weight:
272.39
MDL Number:
MOL File:
1087-07-6.mol
Last updated:2023-04-23 13:52:06
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Cyclopentanone, 2,5-bis(2-thienylmethylene)- Properties

Melting point 226 °C
Boiling point 484.7±45.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Yellow solid

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Chemical Properties,Uses,Production

General Description

A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Cyclopentanone, 2,5-bis(2-thienylmethylene)- PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem 1087-07-6