Adenine
- CAS No.
- 73-24-5
- Chemical Name:
- Adenine
- Synonyms
- 9H-Purin-6-amine;Adenin;6-AMINOPURINE;Vitamin B4;7H-PURIN-6-AMINE;Ade;ANE;Purin-6-amine;1H-PURIN-6-AMINE;6-Amino-9H-purine
- CBNumber:
- CB1323708
- Molecular Formula:
- C5H5N5
- Molecular Weight:
- 135.13
- MDL Number:
- MFCD00041790
- MOL File:
- 73-24-5.mol
- MSDS File:
- SDS
| Melting point | >360 °C (lit.) |
|---|---|
| Boiling point | 238.81°C (rough estimate) |
| Density | 1.3795 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| Flash point | 220°C |
| storage temp. | 2-8°C |
| solubility | 0.5 M HCl: soluble20mg/mL, Grade III, colorless to faint yellow or tan |
| form | Liquid or Solid |
| pka | 4.12(at 25℃) |
| color | Clear colorless to light yellow |
| Odor | Odorless |
| PH Range | 7 |
| Water Solubility | 0.5 g/L (20 ºC) |
| Sublimation | 220 ºC |
| Merck | 14,152 |
| BRN | 5777 |
| Stability | Stable. Moisture-sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | GFFGJBXGBJISGV-UHFFFAOYSA-N |
| LogP | -0.090 |
| CAS DataBase Reference | 73-24-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | ADE; adenine |
| FDA UNII | JAC85A2161 |
| NIST Chemistry Reference | Adenine(73-24-5) |
| EPA Substance Registry System | Adenine (73-24-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU6125000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 orally in rats: 745 mg/kg (Philips) | |||||||||
| NFPA 704 |
|
Adenine price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1152-M | Adenine - CAS 73-24-5 - Calbiochem Synthetic, therefore free of any contamination with related natural products. | 73-24-5 | 10g | $83.4 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1152-M | Adenine - CAS 73-24-5 - Calbiochem Synthetic, therefore free of any contamination with related natural products. | 73-24-5 | 25g | $97.6 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1152-M | Adenine - CAS 73-24-5 - Calbiochem Synthetic, therefore free of any contamination with related natural products. | 73-24-5 | 100g | $332 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1012101 | Adenine United States Pharmacopeia (USP) Reference Standard | 73-24-5 | 200mg | $361 | 2022-05-15 | Buy |
| TCI Chemical | A0149 | Adenine >99.0%(HPLC)(T) | 73-24-5 | 25g | $61 | 2023-01-07 | Buy |
Adenine Chemical Properties,Uses,Production
Description
adenine is one of the purine nitrogenous bases that composes DNA and RNA; composed of two carbon–nitrogen rings. Adenine bonds with thymine in DNA and with uracil in RNA (see base pairing rule); it is also a major component of other molecules such as adenosine triphosphate.
Chemical Properties
Adenine is a prominent member of the family of naturally occurring purines. Adenine occurs not only in ribonucleic acids (RNA), and deoxyribonucleic acids (DNA), but in nucleosides, such as adenosine, and nucleotides, such as adenylic acid, which may be linked with enzymatic functions quite apart from nucleic acids. Adenine, in the form of its ribonucleotide, is produced in mammals and fowls endogenously from smaller molecules and no nutritional essentiality is ascribed to it. In the nucleosides, nucleotides, and nucleic acids, the attachment or the sugar moiety is at position 9.
The purines and pyrimidines absorb ultraviolet light readily, with absorption peaks at characteristic frequencies. This has aided in their identification and quantitative determination.
Physical properties
Adenine is a white to almost white crystalline powder that is an important biological compound found in deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and adenosine triphosphate (ATP). It was once commonly referred to as vitamin B4 but is no longer considered a vitamin. Adenine is derived from purine. Purine is a heterocyclic compound.
History
Adenine is one of the two purines found in DNA and RNA. The other is guanine. Adenine and guanine are called bases in reference to DNA and RNA. A nucleic acid base attached to ribose forms a ribonucleoside. Adenine combined with ribose produces the nucleoside adenosine.
Uses
Adenine is used as an active component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron. It is useful as a local antiseptic and vitamin B4. Further, it is used in the microbial determination of niacin. It is also employed as a food supplement for adult rats to investigate the effects of dietary adenine overload. In addition to this, it is used in the production of nucleotides of the nucleic acids.
Definition
ChEBI: Adenine is the parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. It has a role as a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purine nucleobase and a member of 6-aminopurines. It derives from a hydride of a 9H-purine.
Application
Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coa laninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.
Synthesis Reference(s)
Journal of the American Chemical Society, 88, p. 3829, 1966 DOI: 10.1021/ja00968a028
General Description
Adenine is a purine nucleobase. It is part of DNA, and RNA. Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP). It is a nitrogenous base found in DNA and RNA. It is also a constituent of certain coenzymes and when combined with the sugar ribose it forms the nucleoside adenosine found in AMP, ADP, and ATP. Adenine has a purine ring structure. It is one of the major component bases ofnucleotides and the nucleic acidsDNA and RNA.
Biochem/physiol Actions
Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.
Purification Methods
Crystallise adenine from distilled water. [Beilstein 26 III/IV 3561.]
Adenine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 | overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
| Zhuozhou Wenxi import and Export Co., Ltd | +8613111626072 | zzwenxi@126.com | CHINA | 13170 | 58 |
| XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +8617731987558 | xingjiu@xingjiubiotech.com | China | 1005 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 294 | 55 |
| Hangzhou Measure Life Technology Co., LTD | +8613343730176 | 2924244016@qq.com | China | 80 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 805 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29810 | 60 |
| Henan DaKen Chemical CO.,LTD. | +86-371-66670886 | info@dakenchem.com | China | 18267 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21975 | 55 |
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View Lastest Price from Adenine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-30 | Adenosine Ep Impurity A
73-24-5
|
US $0.00-0.00 / mg | 10mg | 99.90% | 10kg/month | Guangzhou Tosun Pharmaceutical Limited | |
 |
2023-05-30 | Adenine
73-24-5
|
US $0.00 / Kg/Drum | 1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd | |
 |
2023-05-12 | Adenine
73-24-5
|
US $0.00-0.00 / kg | 1kg | 98~102% | 100MT/month | Shanghai Bojing Chemical Co.,Ltd. |
-
- Adenosine Ep Impurity A
73-24-5
- US $0.00-0.00 / mg
- 99.90%
- Guangzhou Tosun Pharmaceutical Limited
-
- Adenine
73-24-5
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Adenine
73-24-5
- US $0.00-0.00 / kg
- 98~102%
- Shanghai Bojing Chemical Co.,Ltd.
73-24-5(Adenine)Related Search:
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