Anti-EpCAM antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-EpCAM antibody, Mouse monoclonal
- Synonyms
- Anti-EpCAM antibody, Mouse monoclonal
- CBNumber:
- CB14669198
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-EpCAM antibody, Mouse monoclonal price More Price(1)
Anti-EpCAM antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-EpCAM antibody has been used in:
- immunofluorescence
- immunohistochemistry
- immunoprecipitation
General Description
Anti-EpCAM antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma Ber-EP4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human breast carcinoma cell line MCF-7. EpCAM (Epithelial cell adhesion molecule) is a highly conserved type I transmembrane glycoprotein. EpCAM is present on most epithelia tissues of the adult body and in undifferentiated rather than differentiated embryonic stem cells.
Biochem/physiol Actions
The epithelial cell adhesion molecule (EpCAM) is highly expressed in carcinomas. It regulates cell signalling, proliferation, migration and adhesion. Proteolytic cleavage of EpICD domain is crucial for tumor progression. EpCAM is highly expressed in breast cancer and is considered as a potential target for gene therapy. Deletions in the 3′ region of the EpCAM gene is associated with colorectal cancer based lynch syndrome. Single nucleotide polymorphism in EpCAM gene is associated with infant diarrheal disorder, congenital tufting enteropathy(CTE).
Anti-EpCAM antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-EpCAM antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |