PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
- CAS No.
- Chemical Name:
- PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
- Synonyms
- PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
- CBNumber:
- CB14817768
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem price More Price(1)
PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem Chemical Properties,Uses,Production
General Description
The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5 μmol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol (Cat. No. 580555) dosage on day zero (60 mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively.
PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |