Pomalidomide-PEG3-NH2 hydrochloride
- CAS No.
- 2380273-75-4
- Chemical Name:
- Pomalidomide-PEG3-NH2 hydrochloride
- Synonyms
- HCl NH2-PEG3-CH2CO-Poma;Pomalidomide-PEG3-NH2 hydrochloride;P933620 Pomalidomide-amino-PEG3-NH2 hydrochloride;2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide hydrochloride
- CBNumber:
- CB14846366
- Molecular Formula:
- C21H27ClN4O8
- Molecular Weight:
- 498.92
- MDL Number:
- MFCD32173776
- MOL File:
- 2380273-75-4.mol
Pomalidomide-PEG3-NH2 hydrochloride Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG3-NH2 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG3-NH2 hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3716 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2893 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4955 | 58 |
SuZhou Medinoah Co.,LTD. | 0512-0512-69561983 13914027025 | he_qf@medinoah.com | China | 3380 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1285 | 58 |
Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 19975279805 | 1900830611@qq.com | China | 952 | 58 |
Abosyn | 0512-69561983 13914027025 | he_qf@medinoah.com | China | 3001 | 58 |
https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29989 | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5019 | 58 |
View Lastest Price from Pomalidomide-PEG3-NH2 hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | Pomalidomide-PEG3-NH2 hydrochloride
2380273-75-4
|
US $0.00 / mg | 100mg | >98.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
- Pomalidomide-PEG3-NH2 hydrochloride
2380273-75-4
- US $0.00 / mg
- >98.00%
- Xian confluore Biological Technology Co., Ltd.