ChemicalBook >> CAS DataBase List >>Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester

CAS No.
1858276-04-6
Chemical Name:
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
Synonyms
TAK-981;Subasumstat;Subasumstat(TAK-981);((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate;(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate;(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate;Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester;inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme
CBNumber:
CB15488093
Molecular Formula:
C25H28ClN5O5S2
Molecular Weight:
578.1
MDL Number:
MFCD32062692
MOL File:
1858276-04-6.mol
Last updated:2024-10-31 18:15:48

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Properties

Boiling point 836.1±75.0 °C(Predicted)
Density 1.474±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 16.67 mg/mL (28.84 mM; ultrasonic and warming and heat to 80°C)
form A solid
pka 9.35±0.70(Predicted)
color White to light yellow
FDA UNII XQ43H3V6M1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C351340 TAK-981 1858276-04-6 2.5mg $1470 2021-12-16 Buy
ChemScene CS-0091878 Subasumstat 98.56% 1858276-04-6 100mg $1650 2021-12-16 Buy
ChemScene CS-0091878 Subasumstat 98.56% 1858276-04-6 5mg $200 2021-12-16 Buy
ChemScene CS-0091878 Subasumstat 98.56% 1858276-04-6 10mg $310 2021-12-16 Buy
American Custom Chemicals Corporation INB0009808 TAK-981 95.00% 1858276-04-6 5MG $454.35 2021-12-16 Buy
Product number Packaging Price Buy
C351340 2.5mg $1470 Buy
CS-0091878 100mg $1650 Buy
CS-0091878 5mg $200 Buy
CS-0091878 10mg $310 Buy
INB0009808 5MG $454.35 Buy

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Chemical Properties,Uses,Production

Uses

TAK-981 is a heteroaryl sulfamate compound useful as inhibitors of SUMO activating enzyme.

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4456 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 6521 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1990 58

View Lastest Price from Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Subasumstat pictures 2024-10-31 Subasumstat
1858276-04-6
US $76.00-163.00 / mg 98.22% 10g TargetMol Chemicals Inc.
  • Subasumstat pictures
  • Subasumstat
    1858276-04-6
  • US $76.00-163.00 / mg
  • 98.22%
  • TargetMol Chemicals Inc.
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester TAK-981 (1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate Subasumstat ((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate Subasumstat(TAK-981) inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme (1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate 1858276-04-6 C25H28ClN5O5S2