AAPK-25
- CAS No.
- 2247919-28-2
- Chemical Name:
- AAPK-25
- Synonyms
- AAPK-25;AAPK-25, 10 mM in DMSO;6-(3,4-Dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide;2-Naphthalenecarboxamide, 6-[(3,4-dichlorobenzoyl)amino]-N-2-thiazolyl-;Aurora Kinase,inhibit,Polo-like Kinase (PLK),AAPK 25,Apoptosis,Inhibitor,AAPK25,AAPK-25
- CBNumber:
- CB15821209
- Molecular Formula:
- C21H13Cl2N3O2S
- Molecular Weight:
- 442.32
- MDL Number:
- MFCD32197231
- MOL File:
- 2247919-28-2.mol
AAPK-25 Chemical Properties,Uses,Production
Uses
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM[1].
in vivo
AAPK-25 enhances survival rate in the BALB/c nude mice tumor xenograft model[1].
References
[1] Qi B, et al. Discovery of inhibitors of Aurora/PLK targets as anti-cancer agents. J Med Chem. 2019 Aug 5. DOI:10.1021/acs.jmedchem.9b00353
AAPK-25 Preparation Products And Raw materials
Raw materials
Preparation Products
AAPK-25 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 39966 | 60 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2391 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 8011 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4809 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
View Lastest Price from AAPK-25 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-06 | AAPK-25
2247919-28-2
|
US $52.00-191.00 / mg | 97.05% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-06 | AAPK-25
2247919-28-2
|
US $52.00-191.00 / mg | 97.05% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-28 | AAPK-25
2247919-28-2
|
US $87.00-318.00 / mg | 97.79% | 10g | TargetMol Chemicals Inc. |
