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Zapalog

Zapalog structure

CAS No.: 1708091-24-0

Chemical Name:: Zapalog

Synonyms: Zapalog;2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-[3-[[4-[4-[1-[2-[4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]ethoxy]ethyl]-2-methoxy-5-nitrophenoxy]-1-oxobutyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-

CBNumber:: CB15821229

Molecular Formula:: C58H73N7O15

Molecular Weight:: 1108.24

MDL Number:: MFCD32201094

MOL File:: 1708091-24-0.mol

Last updated:2025-04-18 09:51:42

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Zapalog Properties

Density	1.260±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (90.23 mM; Need ultrasonic)
form	Solid
pka	14.46±0.70(Predicted)
color	White to yellow

Zapalog Chemical Properties,Uses,Production

Uses

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].

References

[1] Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21(6):768-777. DOI:10.1038/s41556-019-0317-2

Zapalog Preparation Products And Raw materials

Raw materials

Preparation Products

Zapalog Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32239	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12306	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9729	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29774	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9835	58
Adooq Bioscience LLC	400-025-6535	sales@adooq.cn	China	18215	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
RD International Technology Co., Limited	58
Adooq Bioscience LLC	58

Zapalog 2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-[3-[[4-[4-[1-[2-[4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]ethoxy]ethyl]-2-methoxy-5-nitrophenoxy]-1-oxobutyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- 1708091-24-0 C58H73N7O15