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NMS-P515

NMS-P515 Structure
NMS-P515 structure
CAS No.
1262395-13-0
Chemical Name:
NMS-P515
Synonyms
NMS-P515;NMS-P-515,NMS P515,NMSP515;1H-Isoindole-4-carboxamide, 2-(1-cyclohexyl-4-piperidinyl)-2,3-dihydro-1-methyl-3-oxo-, (1S)-
CBNumber:
CB15821274
Molecular Formula:
C21H29N3O2
Molecular Weight:
355.47
MDL Number:
MFCD32067978
MOL File:
1262395-13-0.mol
Last updated:2025-10-28 16:00:23
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NMS-P515 Properties

Boiling point 513.3±50.0 °C(Predicted)
Density 1.200±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 15.80±0.40(Predicted)
form Solid
color White to off-white

NMS-P515 Chemical Properties,Uses,Production

Description

NMS-P515 is a potent inhibitor of PARP-1 both in biochemical (Kd: 0.016 μM) and cellular (IC50: 0.027 μM) assays.

Uses

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity[1].

in vivo

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer[1].

Animal Model:Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts[1].
Dosage:80 mg/kg.
Administration:Orally, once daily for 12 days.
Result:Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).

IC 50

PARP-1: 16 nM (Kd); PARP-1: 27 nM (IC50, in Hela cells)

References

[1] Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10(4):534-538. DOI:10.1021/acsmedchemlett.8b00569

NMS-P515 Preparation Products And Raw materials

Raw materials

Preparation Products

NMS-P515 Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1248 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29257 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Beijing Biocreative Technology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Adooq Bioscience LLC 58

View Lastest Price from NMS-P515 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NMS-P515 pictures 2025-10-27 NMS-P515
1262395-13-0
 US $2590.00-1310.00 / mg 10g TargetMol Chemicals Inc.
  • NMS-P515 pictures
  • NMS-P515
    1262395-13-0
  • US $2590.00-1310.00 / mg
  • TargetMol Chemicals Inc.
NMS-P515 1H-Isoindole-4-carboxamide, 2-(1-cyclohexyl-4-piperidinyl)-2,3-dihydro-1-methyl-3-oxo-, (1S)- NMS-P-515,NMS P515,NMSP515 1262395-13-0