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ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Structure
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- structure
CAS No.
2488761-03-9
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]-
Synonyms
Pom-8PEG;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]-
CBNumber:
CB18219339
Molecular Formula:
C29H43N3O12
Molecular Weight:
625.66
MDL Number:
MOL File:
2488761-03-9.mol
Last updated:2025-04-18 09:51:43
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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Properties

Boiling point 786.6±60.0 °C(Predicted)
Density 1.301±0.06 g/cm3(Predicted)
pka 10.74±0.40(Predicted)
form Viscous Liquid
color Light green to green

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Chemical Properties,Uses,Production

Uses

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].

IC 50

Cereblon

References

[1] Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953. DOI:10.1016/j.apsb.2020.02.010

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Amatek Scientific Co. Ltd. 0512-56316828 info@amateksci.com China 28785 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59936 58
Shanghai Huici Pharmaceutical Technology Co., LTD 133-31922809 19372841038 lixing@pharmahuici.com China 732 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29257 58
Supplier Advantage
Amatek Scientific Co. Ltd. 58
Bide Pharmatech Ltd. 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- Pom-8PEG 2488761-03-9