ChemicalBook >> CAS DataBase List >>2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]-

2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]-

2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- structure

CAS No.: 1189805-10-4

Chemical Name:: 2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]-

Synonyms: D7-Oxprenolol;1-(2-(allyloxy)phenoxy)-3-((propan-2-yl-d7)amino)propan-2-ol;2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]-

CBNumber:: CB19313942

Molecular Formula:: C15H16D7NO3

Molecular Weight:: 272.39

MDL Number:

MOL File:: 1189805-10-4.mol

Last updated:2025-07-27 11:21:22

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2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- Properties

Boiling point	403.282±40.00 °C(Press: 760.00 Torr)(predicted)
Density	1.040±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	-20°C
solubility	DMF: soluble,DMSO: soluble,Methanol: soluble
form	A solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
3		0

2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- Chemical Properties,Uses,Production

Uses

Oxprenolol-d7 is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].

Biological Activity

Oxprenolol-d7 is intended for use as an internal standard for the quantification of oxprenolol by GC- or LC-MS. Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue).1 It is non-selective and binds to both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively).2 Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively).3,4 Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.5

References

1.Nagatomo, T., Sasaki, M., Tsuchihashi, H., et al.Binding characteristics of 3H-dihydroalprenolol to β-adrenoceptors of rat heart treated with neuraminidaseJpn. J. Pharmacol.33(4)851-857(1983) 2.Abrahamsson, T.The β1- and β2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: A study in the isolated right atrium and uterus of the ratBr. J. Pharmac.87(4)657-664(1986) 3.Moretti-Rojas, I., Ezrailson, E.G., Birnbaumer, L., et al.Serotonergic and adrenergic regulation of skeletal muscle metabolism in the rat. II. The use of [125I]iodolysergic acid diethylamide and [125I]iodopindolol as probes of sarcolemmal receptor function and specificityJ. Biol. Chem.258(20)12499-12508(1983) 4.Langlois, M., Brémont, B., Rousselle, D., et al.Structural analysis by the comparative molecular field analysis method of the affinity of β-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptorsEur. J. Pharmacol.244(1)77-87(1993) 5.Russo, M.E., and Covinsky, J.O.Oxprenolol hydrochloride: Pharmacology, pharmacokinetics, adverse effects and clinical efficacyPharmacotherapy3(2)68-81(1983)

2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- Suppliers

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1-(2-(allyloxy)phenoxy)-3-((propan-2-yl-d7)amino)propan-2-ol 2-Propanol, 1-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-3-[2-(2-propen-1-yloxy)phenoxy]- D7-Oxprenolol 1189805-10-4