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CAY10784

CAY10784 Structure
CAY10784 structure
CAS No.
1245814-52-1
Chemical Name:
CAY10784
Synonyms
CAY10784;STAT3-IN-17;CAY10784,CAY-10784;N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide;Benzamide, N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-
CBNumber:
CB19739401
Molecular Formula:
C11H6F3N3O3S
Molecular Weight:
317.24
MDL Number:
MOL File:
1245814-52-1.mol
Last updated:2023-05-21 10:59:17
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CAY10784 Properties

Density 1.615±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
form A crystalline solid
pka 5.82±0.50(Predicted)

CAY10784 Chemical Properties,Uses,Production

Biological Activity

CAY10784 is a STAT3 inhibitor (IC50 = 0.74 μM in a reporter assay) and a derivative of WP1066 .1 It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 μM, respectively).2

References

1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitorsACS Med. Chem. Lett.(2021) 2.Ballard, T.E., Wang, X., Olekhnovich, I., et al.Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activityChemMedChem6(2)362-377(2011)

CAY10784 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10784 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3501 55
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Shaoguan Qicheng Biotechnology Co., Ltd 18122215013 780229652@qq.com China 947 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ChemeGen 中国 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shaoguan Qicheng Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10784 CAY10784,CAY-10784 Benzamide, N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)- N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide STAT3-IN-17 1245814-52-1