Erythromycin A Enol Ether
- CAS No.
- 33396-29-1
- Chemical Name:
- Erythromycin A Enol Ether
- Synonyms
- EM 523;Isoniazid Impurity 16;Erythromycin impurity B;Erythromycin Impurity 5;Erythromycin impurity 05;Erythromycin A Enol Ether;Erythromycin A Enol EtherI;JFVYXJKGJMUGRG-POECJHBWSA-N;Erythromycin Estolate Impurity E;Erythromycin A enol ether, EvoPure
- CBNumber:
- CB21176304
- Molecular Formula:
- C37H65NO12
- Molecular Weight:
- 715.91
- MDL Number:
- MFCD09840536
- MOL File:
- 33396-29-1.mol
| Melting point | 133-1350C |
|---|---|
| Boiling point | 791.6±60.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.45±0.70(Predicted) |
| color | White to Pale Yellow |
| CAS DataBase Reference | 33396-29-1 |
| FDA UNII | 32B40I7V7B |
Erythromycin A Enol Ether price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 05238 | Erythromycin A enol ether analytical standard | 33396-29-1 | 5mg | $655 | 2024-03-01 | Buy |
| Cayman Chemical | 17191 | Erythromycin A enol ether ≥95% | 33396-29-1 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 17191 | Erythromycin A enol ether ≥95% | 33396-29-1 | 5mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 17191 | Erythromycin A enol ether ≥95% | 33396-29-1 | 10mg | $257 | 2024-03-01 | Buy |
| TRC | E649970 | Erythromycin A enol ether | 33396-29-1 | 50mg | $910 | 2021-12-16 | Buy |
Erythromycin A Enol Ether Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Erythromycin A Enol Ether (Erythromycin EP Impurity E) is an impurity of Erythromycin.
Uses
Erythromycin A enol ether is a degradation product of erythromycin formed under acidic conditions by C6–OH internal attack on the C9 ketone to produce a cyclic enol ether. The rearrangement results in a loss of antibiotic activity. This single reaction was the prime driver for the development of second and third generation erythromycins. Erythromycin A enol ether is an important standard for stability studies.
Definition
ChEBI: Erythromycin a enol ether is an aminoglycoside.
Biological Activity
erythromycin a enol ether, also known as 8,9-anhydroerythromycin a 6,9 hemiketal, is a kind of catabolite of erythromycin a without its antibiotic properties.erythromycin a enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. erythromycin a enol ether is also the agent of gastrointestinal (gi) distress [1].motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.
References
[1] steinmetz w e, shapiro b l, roberts j j, et al. the structure of erythromycin enol ether as a model for its activity as a motilide.[j]. journal of medicinal chemistry, 2002, 45(22): 4899-4902.
Erythromycin A Enol Ether Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Beijing Comparison Pharmaceutical Technology Co., Ltd | 010-52878169 15701683040 | sales@bjcomparison.com | China | 4713 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
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