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BN-104

BN-104 Structure
BN-104 structure
CAS No.
2938995-50-5
Chemical Name:
BN-104
Synonyms
BN-104;BN-104(BNM-1192);2-[6-[2-(4-Cyclopropyl-5-pyrimidinyl)-4-fluorophenoxy]-1,2,4-triazin-5-yl]-2,7-diazaspiro[3.5]nonan-7-yl][(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl]methanone;Methanone, [2-[6-[2-(4-cyclopropyl-5-pyrimidinyl)-4-fluorophenoxy]-1,2,4-triazin-5-yl]-2,7-diazaspiro[3.5]non-7-yl][(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl]-
CBNumber:
CB214249745
Molecular Formula:
C31H35FN8O2
Molecular Weight:
570.66
MDL Number:
MOL File:
2938995-50-5.mol
Last updated:2025-04-17 18:22:24
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BN-104 Properties

Boiling point 774.857±70.00 °C(Press: 760.00 Torr)(predicted)
Density 1.425±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 10.265±0.40(predicted)
form Solid
color White to off-white

BN-104 Chemical Properties,Uses,Production

Uses

BN-104 (BNM-1192) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a Menin inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein. BN-104 is a weak hERG inhibitor, with an IC50 greater than 100 μM. BN-104 has anti-tumor activity and can be used in cancer research, such as for acute myeloid leukemia[1].

in vivo

BN-104 (0-60 mg/kg, oral, twice a day, 21 days) inhibits tumor proliferation in a mouse model[1].

Animal Model:MV-4-11 xenograft mouse model[1]
Dosage:0, 10, 30, 60 mg/kg; twice a day; 21 days
Administration:Oral
Result:Inhibited tumor proliferation.

IC 50

hERG: >100 μM (IC50)

References

[1] Taishan Hu, et al. "Discovery of a novel menin-MLL inhibitor for potential treatment of MLLr leukemias and NPM1c AML." Cancer Research. Vol. 82. No. 12. 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH, 2022.

BN-104 Preparation Products And Raw materials

Raw materials

Preparation Products

BN-104 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Soochow Chirally Material Science and Technology Co.,Ltd 		+86-51266834346 +86-17751128648 sales@krl-tech.com China 942 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3506 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 15000803246 18149758185 sales-cpd@caerulumpharma.com China 413 58
Soochow Chirally Material Science and Technology Co.,Ltd 0512-66834346 17751187418 sales@krl-tech.com China 1092 58
Shaoyuan Technology (Shanghai) Co., Ltd. 021-50795510 4000665055 sy-c6@accelachem.com China 10000 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13011 58
Supplier Advantage
Soochow Chirally Material Science and Technology Co.,Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Soochow Chirally Material Science and Technology Co.,Ltd 58
Shaoyuan Technology (Shanghai) Co., Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58
BN-104 Methanone, [2-[6-[2-(4-cyclopropyl-5-pyrimidinyl)-4-fluorophenoxy]-1,2,4-triazin-5-yl]-2,7-diazaspiro[3.5]non-7-yl][(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl]- 2-[6-[2-(4-Cyclopropyl-5-pyrimidinyl)-4-fluorophenoxy]-1,2,4-triazin-5-yl]-2,7-diazaspiro[3.5]nonan-7-yl][(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl]methanone BN-104(BNM-1192) 2938995-50-5