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Maxacalcitol

Maxacalcitol structure

CAS No.: 103909-75-7

Chemical Name:: Maxacalcitol

Synonyms: MAXACALCITOL;Macalciferol;Oxacalcitriol;Maxacalcitol (22-Oxacalcitriol);22-Oxa-1α,25-dihydroxycholecalciferol;(5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol;(+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol;4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol;(1R,3S,Z)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

CBNumber:: CB22130916

Molecular Formula:: C26H42O4

Molecular Weight:: 418.61

MDL Number:: MFCD00871502

MOL File:: 103909-75-7.mol

Last updated:2023-09-04 15:50:00

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Maxacalcitol Properties

Melting point	122°
alpha	D20 +49.4° (c = l.00 in ethanol)
Boiling point	581.4±50.0 °C(Predicted)
Density	1.09±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO
form	crystalline solid
pka	14.43±0.40(Predicted)
InChIKey	DTXXSJZBSTYZKE-ZDQKKZTESA-N
SMILES	[C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1
FDA UNII	N2UJM5NBF6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H361

Precautionary statements

P281-P301+P310

NFPA 704

	0
4		0

Maxacalcitol price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10794	22-Oxacalcitriol ≥95%	103909-75-7	500μg	$68	2024-03-01	Buy
Cayman Chemical	10794	22-Oxacalcitriol ≥95%	103909-75-7	1mg	$122	2024-03-01	Buy
Cayman Chemical	10794	22-Oxacalcitriol ≥95%	103909-75-7	5mg	$442	2024-03-01	Buy
TRC	O752350	22-Oxacalcitriol	103909-75-7	5mg	$435	2021-12-16	Buy
ChemScene	CS-0392	Maxacalcitol 99.71%	103909-75-7	25mg	$1620	2021-12-16	Buy

Product number	Packaging	Price	Buy
10794	500μg	$68	Buy
10794	1mg	$122	Buy
10794	5mg	$442	Buy
O752350	5mg	$435	Buy
CS-0392	25mg	$1620	Buy

Maxacalcitol Chemical Properties,Uses,Production

Description

Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.

Originator

Chugai (Japan)

Uses

22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.

Definition

ChEBI: Maxacalcitol is an organic molecular entity.

brand name

Prezios (Chugai Pharmaceutical Co., Ltd., Japan);Prezios, Oxarol.

Maxacalcitol synthesis

Synthesis of Maxacalcitol from Methyllithium and Propanoic acid, 3-[(1S)-1-[(1S,3aS,4E,7aS)-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-, ethyl este

Maxacalcitol Preparation Products And Raw materials

Raw materials

Propanoic acid, 3-[(1S)-1-[(1S,3aS,4E,7aS)-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-, ethyl este Methyllithium

Preparation Products

Maxacalcitol Suppliers

Global( 143)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Bonster Technology Co.,Limited	+8613315996897	bsterltd.wendy@gmail.com	China	796	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing Dolon Biotechnology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hebei Bonster Technology Co.,Limited	58
TargetMol Chemicals Inc.	58
Longyan Tianhua Biological Technology Co., Ltd	58
Career Henan Chemica Co	58

View Lastest Price from Maxacalcitol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	Maxacalcitol 103909-75-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Maxacalcitol 103909-75-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-12-27	Maxacalcitol 103909-75-7	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

Maxacalcitol
103909-75-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Maxacalcitol
103909-75-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Maxacalcitol
103909-75-7
US $1.00 / KG
99%
Career Henan Chemical Co

Maxacalcitol Spectrum

Maxacalcitol(103909-75-7)¹HNMR

103909-75-7(Maxacalcitol)Related Search:

Rivaroxaban Alfacalcidol ELOCALCITOL 1,2-DIMETHYLENE-CYCLOHEXANE Maxacalcitol

MAXACALCITOL (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol 22-Oxa-1α,25-dihydroxycholecalciferol Oxacalcitriol (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)- (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol (1R,3S,Z)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Maxacalcitol (22-Oxacalcitriol) (1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-Hydroxy-3-methylbutoxy)ethyl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol Macalciferol 103909-75-7 909-75-7 API