(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
- CAS No.
- 1303993-73-8
- Chemical Name:
- (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
- Synonyms
- CHPG Sodium salt;(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
- CBNumber:
- CB22518684
- Molecular Formula:
- C8H7ClNNaO3
- Molecular Weight:
- 225.6
- MDL Number:
- MFCD11100366
- MOL File:
- 1303993-73-8.mol
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3695 | CHPGSodiumsalt ≥99%(HPLC) | 1303993-73-8 | 10 | $139 | 2021-12-16 | Buy |
| Tocris | 3695 | CHPGSodiumsalt ≥99%(HPLC) | 1303993-73-8 | 50 | $574 | 2021-12-16 | Buy |
| TRC | C381358 | CHPGSodiumSalt | 1303993-73-8 | 100mg | $915 | 2021-12-16 | Buy |
| Usbiological | 254968 | CHPG Sodium salt | 1303993-73-8 | 10mg | $380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009839 | (R,S)-CHPG SODIUM SALT 95.00% | 1303993-73-8 | 5MG | $450.77 | 2021-12-16 | Buy |
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Chemical Properties,Uses,Production
Uses
CHPG Sodium Salt (cas# 1303993-73-8) is a useful research chemical.Also, it is derived from 2-Chloro-5-hydroxybenzaldehyde (C368225), which is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.
Biological Activity
CHPG sodium salt is a selective mGluR5 agonist and attenuates SO2-induced oxidative stress and inflammation in BV2 microglia via the TSG-6/NF-κB pathway. It prevents traumatic brain injury (TBI) in vitro and in vivo through the ERK and Akt pathways.
in vitro
CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
It protects BV2 cells against SO 2 -induced apoptosis.
It treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500 μM |
| Incubation Time: | 24 hours |
| Result: | Increased the cell viability. |
| Cell Line: | BV2 microglial cells | < /tr>
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
in vivo
CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM < /td> |
| Administration: | Injection; for 7 days |
| Reduced significantly cerebral lesion volume. |
target
| mGlu 5
| NF-κB
| ERK
| Akt
|
storage
+4°C (desiccate)
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Preparation Products And Raw materials
Raw materials
Preparation Products
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |