TRX-0237 mesylate
- CAS No.
- 1236208-20-0
- Chemical Name:
- TRX-0237 mesylate
- Synonyms
- Hydromethylthionine mesylate;CS-2892;Leucomethylene;RX-0237 mesylate;TRX-0237 mesylate;TRx0237 (LMTX) mesylate;TRX0237 (LMTX) , (CH3SO3H);Leucomethylene Blue Dimesylate;Leucomethylene blue (Mesylate);Leucomethylene blue Mesylate, >98%
- CBNumber:
- CB23119756
- Molecular Formula:
- C16H19N3S.2(CH4O3S)
- Molecular Weight:
- 477.61848
- MDL Number:
- MFCD29764308
- MOL File:
- 1236208-20-0.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:102.5(Max Conc. mg/mL);214.61(Max Conc. mM) H2O:54.0(Max Conc. mg/mL);113.06(Max Conc. mM) |
| form | A solid |
| FDA UNII | 3248SEF29D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TRX-0237 mesylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD11319607 | LeucomethyleneBlueMesylate 97% | 1236208-20-0 | 5mg | $40 | 2021-12-16 | Buy |
| CSNpharm | CSN17257 | LeucomethyleneBlueMesylate | 1236208-20-0 | 5mg | $48 | 2021-12-16 | Buy |
| Crysdot | CD11319607 | LeucomethyleneBlueMesylate 97% | 1236208-20-0 | 10mg | $55 | 2021-12-16 | Buy |
| Crysdot | CD11319607 | LeucomethyleneBlueMesylate 97% | 1236208-20-0 | 50mg | $173 | 2021-12-16 | Buy |
| DC Chemicals | DC10217 | TRx0237(LMTX)mesylate >98% | 1236208-20-0 | 100mg | $250 | 2021-12-16 | Buy |
TRX-0237 mesylate Chemical Properties,Uses,Production
Biological Activity
TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor. For the treatment of Alzheimer's disease and frontotemporal dementia.
in vitro
TRx 0237 (LMTX?) is a second-generation tau aggregation inhibitor for the treatment of Alzheimer's disease and frontotemporal dementia. It is a purified form of methylene blue, an ancient drug widely used in Africa to treat malaria and methemoglobinemia. In vitro experiments demonstrated that 0.16 μM TRx 0237 interfered with double helical filaments (PHF) isolated from Alzheimer's disease patient brain tissue.
in vivo
TRX-0237 mesylate dose-dependently rescues learning impairment in L1 (a mouse strain overexpressing truncated tau protein) and restores its behavioral resilience in the water maze test (minimum dose administered: 9 mg MT/kg). In L66 (a mouse strain overexpressing full-length tau-P301S/G335D), it modulates its motor learning (effective dose: 4 mg MT/kg). It reduced the number of tau-active neurons, especially in the hippocampus and entorhinal cortex of L1, and more generally in the L66 strain.
target
| Target | Value |
| tau protein aggregation |
TRX-0237 mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
