488793-85-7
- CAS No.
- 488793-85-7
- Chemical Name:
- 488793-85-7
- Synonyms
- ARN272;ARN-272
- CBNumber:
- CB23145843
- Molecular Formula:
- C27H20N4O2
- Molecular Weight:
- 432.47
- MDL Number:
- MOL File:
- 488793-85-7.mol
488793-85-7 price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 11244 | ARN272 | 488793-85-7 | 1mg | $36 | 2021-12-16 | Buy |
Cayman Chemical | 11244 | ARN272 | 488793-85-7 | 5mg | $150 | 2021-12-16 | Buy |
Cayman Chemical | 11244 | ARN272 | 488793-85-7 | 10mg | $250 | 2021-12-16 | Buy |
Axon Medchem | Axon 2941 | ARN 272 98% | 488793-85-7 | 25mg | $330 | 2021-12-16 | Buy |
Axon Medchem | Axon 2941 | ARN 272 98% | 488793-85-7 | 2x25mg | $550 | 2021-12-16 | Buy |
488793-85-7 Chemical Properties,Uses,Production
Uses
ARN 272 is a a competitive antagonist of the interaction of anandamide with FAAH-like anandamide transporter (FLAT), that lacks amidase activity but binds anandamide with low micromolar affinity and facilitates its translocation into cells.
Enzyme inhibitor
This FLAT inhibitor (FW = 432.47 g/mol; CAS 488793-85-7), also named 4-[[4-(4-hydroxy-phenyl)-1-phthalazinyl]amino]-N-phenylbenzamide, targets the FAAH-Like Anandamide Transporter (IC50 = 1.8 μM), a catalytically silent variant of fatty acid amide hydrolase-1 (FAAH-1) that drives anandamide transport. Mode of Action: The intensity and duration of anandamide signaling appear to be controlled by a two-step elimination process, in which the anandamide or an anandamide-like substance is first internalized by neurons and astrocytes through the action of FLAT and then undergoes hydrolysis through the action of the intracellular membrane- bound amidases, FAAH-1 and FAAH-2. ARN-272 attenuates anandamide internalization, thereby reducing its deactivation. ARN272 competitively antagonizes [ 3 H]-anandamide binding to FLAT (IC50 = 1.8 μM) and inhibits [ 3 H]-anandamide accumulation in both FLAT-expressing Hek293 cells (IC50 ≈ 3 μM) and primary cultures of cortical neurons prepared from rats or wild-type mice. By contrast, ARN272 is without significant effect on the residual [ 3 H]-anandamide accumulation observed in cortical transport system may also facilitate the release of this lipid mediator from cells It also exhibits analgesic effects in rodent models of CB1 endocannabinoid receptor-mediated nociceptive and inflammatory pain.
488793-85-7 Preparation Products And Raw materials
Raw materials
Preparation Products
488793-85-7 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4153 | 55 | |
Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |