ONO-0300302
- CAS No.
- 856689-51-5
- Chemical Name:
- ONO-0300302
- Synonyms
- ONO-0300302;1H-Pyrrole-3-propanoic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-
- CBNumber:
- CB24668310
- Molecular Formula:
- C29H35NO5
- Molecular Weight:
- 477.59
- MDL Number:
- MOL File:
- 856689-51-5.mol
ONO-0300302 Chemical Properties,Uses,Production
Biological Activity
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1]. ONO-0300302 shows moderate stability against rat microsomes[1]. ONO-0300302 inhibits significantly an LPA (lysophosphatidic acid receptor)-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h[1].
References
[1]. Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286.
ONO-0300302 Preparation Products And Raw materials
Raw materials
Preparation Products
ONO-0300302 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24024 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |