Anti-CD4FITC antibody, Mouse monoclonal

Uses

FITC Conjugated Monoclonal Anti-Human CD4 has been used for:

• identification, quantification and monitoring of helper/inducer T cells in peripheral blood, biological fluids, lymphoid organs, and other tissues
• analysis of T cell mediated cytotoxicity
• characterization of subtypes of T cell leukemias and lymphomas
• studies of T cells in health and disease
• flow cytometry

General Description

CD4, a glycoprotein, is predominantly expressed on the cell membrane of mature, thymus-derived (T) lymphocyte and also to some extent in the monocyte/macrophage lineage. It has a transmembrane domain, cytoplasmic region and an extracellular region of four tandem domain similar like members of Ig superfamily.

Biochem/physiol Actions

Immunoregulatory T cell subset abnormalities in autoimmunity disorders, immunodeficiency diseases, graft versus host disease and following immunosuppressive therapy are often manifested as a change in CD4+/CD8+ ratio in peripheral blood T cells.