Anti-E-Selectin (CD62E) antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-E-Selectin (CD62E) antibody, Mouse monoclonal
- Synonyms
- Anti-E-Selectin (CD62E) antibody, Mouse monoclonal
- CBNumber:
- CB24669201
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-E-Selectin (CD62E) antibody, Mouse monoclonal price More Price(1)
Anti-E-Selectin (CD62E) antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-E-Selectin (CD62E) antibody, Mouse monoclonal has been used in immunofluorescence.
General Description
Monoclonal anti-E-selectin (CD62E) (mouse IgG1 isotype) is derived from the 1.2B6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with TNF-α activated human endothelial cells. This antibody reacts specifically with E-selectin (CD62E) expressed on the surface of activated endothelial cells. The antibody may weakly cross-react with recombinant human P-selectin and human platelet P-selectin. Cross-reactivity has been observed with porcine E-selectin.
It is a 140KDa protein mainly expressed in endothelial cells. E- selectin is characterized with an N-terminal domain, epidermal growth factor (EGF)-like domain, lectin (ligand-binding) domain, variable short consensus repeats and transmembrane domain.
Biochem/physiol Actions
E-selectin acts as a key inflammatory cytokine. E-selectin-dependent rolling helps in binding pancreatic cancer cell to hyaluronic acid. In addition, the encoded protein in association with P-selectins, plays a vital role in recruiting leukocytes to inflammatory sites. Mutation in the gene is associated with the development of various diseases such as atherosclerosis and stroke.
Anti-E-Selectin (CD62E) antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-E-Selectin (CD62E) antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |