Sorbitol Dehydrogenase (SDH)
- CAS No.
- Chemical Name:
- Sorbitol Dehydrogenase (SDH)
- Synonyms
- Sorbitol Dehydrogenase (SDH)
- CBNumber:
- CB24670605
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Sorbitol Dehydrogenase (SDH) price More Price(1)
Sorbitol Dehydrogenase (SDH) Chemical Properties,Uses,Production
Uses
Reduces L-iditol to L-sorbose. Also acts on D-glucitol and other closely related sugar alcohols. Allows the reduction of ketones to polyols (see aldolases for the synthesis of ketoses).
General Description
L-iditol:NAD+ 5′-oxidoreductase
Sorbitol dehydrogenase (SDH) from sheep liver has a molar mass of 152kDa. The protein is a tetramer of four identical subunits. Each of these subunits has 355 amino acid residues, of which 10 are cysteine residues. Each subunit contains a zinc atom at the active site, which is associated with three protein ligands and a water molecule. The zinc atom associates with the oxygen of the sorbitol hydroxyl or of the fructose carbonyl interconverted during catalysis.
Biochem/physiol Actions
Sorbitol dehydrogenase (SDH) catalyzes the reversible NAD-linked conversion of D-sorbitol to D-fructose and forms a part of the sorbitol pathway, which is a crucial bypass to glycolysis for glucose metabolism. This pathway has been found to be associated with the accumulation of sorbitol in lens, which results in diabetic cataractogenesis. SDH also oxidizes various polyols and other secondary alcohols into their corresponding ketones.
Sorbitol Dehydrogenase (SDH) Preparation Products And Raw materials
Raw materials
Preparation Products
Sorbitol Dehydrogenase (SDH) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |