JND3229
- CAS No.
- 2260886-64-2
- Chemical Name:
- JND3229
- Synonyms
- JND3229;JND3229 (JND-3229;JND3229, 10 mM in DMSO;JND3229;JND-3229;JND 3229;N-(trans-4-(3-(2-Chlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)cyclohexyl)propionamide;N-[(1r,4r)-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidin-1-yl]cyclohexyl]propanamide;Propanamide, N-[trans-4-[3-(2-chlorophenyl)-3,4-dihydro-7-[[3-methyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl]-
- CBNumber:
- CB24844930
- Molecular Formula:
- C33H41ClN8O2
- Molecular Weight:
- 617.18
- MDL Number:
- MFCD32644591
- MOL File:
- 2260886-64-2.mol
JND3229 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0078820 | JND3229 99.38% | 2260886-64-2 | 5mg | $395 | 2021-12-16 | Buy |
| ChemScene | CS-0078820 | JND3229 99.38% | 2260886-64-2 | 10mg | $605 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573230 | JND3229 >98% | 2260886-64-2 | 5mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573230 | JND3229 >98% | 2260886-64-2 | 10mg | $1283.5 | 2021-12-16 | Buy |
| ChemScene | CS-0078820 | JND3229 99.38% | 2260886-64-2 | 50mg | $1850 | 2021-12-16 | Buy |
JND3229 Chemical Properties,Uses,Production
Uses
JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma[1].
in vivo
JND3229 (10 mg/kg; i.p.; twice daily for 10 days) exhibits an obvious suppression of tumor growth, and shows target inhibition in vivo[1].
| Animal Model: | BALB/c mice (bearing established BaF3-EGFR19D/T790M/C797S mouse xenograft tumors model)[1]. |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; twice daily for 10 days. |
| Result: | Caused an obvious suppression of tumor growth with a Tumor Growth Inhibition (TGI) value of 42.2%. Showed well tolerance without obvious body weight loss or other obvious toxic sign in the treated animals. Significantly decreased the level of phosphorylated EGFR (p-EGFR) tin the tumor tissues. |
References
[1] Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127. DOI:10.1021/acsmedchemlett.8b00373
JND3229 Preparation Products And Raw materials
Raw materials
Preparation Products
JND3229 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2827 | 58 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-027-87342388 18086026008 | sales@kaymke.com | China | 3796 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |