ChemicalBook >> CAS DataBase List >>5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione structure

CAS No.: 2375815-63-5

Chemical Name:: 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione

Synonyms: EX-A4254;CD73-IN-3;LY-3475070;LY-3475070 ，S9867;CD73-IN-3, 10 mM in DMSO;Inhibitor,cancer,CD73 IN 3,CD-73-IN-3,CD73IN3,CD73,Immunosuppression,tumor,inhibit;5-[5-[(1S,2R)-2-isopropylcyclopropyl]-6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione;5-[6-Methyl-5-[(1S,2R)-2-propan-2-ylcyclopropyl]pyridazin-3-yl]-1H-pyrimidine-2,4-dione;5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione

CBNumber:: CB25847774

Molecular Formula:: C15H18N4O2

Molecular Weight:: 286.34

MDL Number:: MFCD33029253

MOL File:: 2375815-63-5.mol

Last updated:2025-12-03 18:03:33

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5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione Properties

Density	1.245±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (349.25 mM; Need ultrasonic)
pka	7.25±0.10(Predicted)
form	Solid
color	White to off-white
InChI	InChI=1/C15H18N4O2/c1-7(2)9-4-11(9)10-5-13(19-18-8(10)3)12-6-16-15(21)17-14(12)20/h5-7,9,11H,4H2,1-3H3,(H2,16,17,20,21)/t9-,11+/s3
InChIKey	WHRUIISQCORGKK-KEGWAHOBNA-N
SMILES	C([C@H]1C[C@@H]1C1=C(N=NC(C2=CNC(=O)NC2=O)=C1)C)(C)C \|&1:1,3,r\|
FDA UNII	AKA9175T4N

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione Chemical Properties,Uses,Production

Uses

CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1].

References

[1] Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@tcypharm.com	China	597	55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 18971495150;	sales@sun-shinechem.com	China	1077	64

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Kaixin Chemical (Hong Kong) Limited	55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	64

View Lastest Price from 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-03	CD73-IN-3 2375815-63-5	US $58.00-238.00 / mg		99.76%	10g	TargetMol Chemicals Inc.

CD73-IN-3
2375815-63-5
US $58.00-238.00 / mg
99.76%
TargetMol Chemicals Inc.

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione Spectrum

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione(2375815-63-5)¹HNMR

5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione LY-3475070 5-[6-Methyl-5-[(1S,2R)-2-propan-2-ylcyclopropyl]pyridazin-3-yl]-1H-pyrimidine-2,4-dione EX-A4254 Inhibitor,cancer,CD73 IN 3,CD-73-IN-3,CD73IN3,CD73,Immunosuppression,tumor,inhibit 5-[5-[(1S,2R)-2-isopropylcyclopropyl]-6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione CD73-IN-3 CD73-IN-3, 10 mM in DMSO LY-3475070 ，S9867 2375815-63-5