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GFB-8438

GFB-8438 Structure
GFB-8438 structure
CAS No.
2304549-73-1
Chemical Name:
GFB-8438
Synonyms
GFB-8438;GFB-8438 ，S0750;GFB-8438, 10 mM in DMSO;4-chloro-5-(3-oxo-4-(2-(trifluoromethyl)benzyl)piperazin-1-yl)pyridazin-3(2H)-one;4-Chloro-5-[3-oxo-4-(2-trifluoromethyl-benzyl)-piperazin-1-yl]-2H-pyridazin-3-one;3(2H)-Pyridazinone, 4-chloro-5-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]-1-piperazinyl]-;mouse,selective,Transient receptor potential channels,Inhibitor,inhibit,remodeling,TRP Channel,deoxycorticosterone,GFB 8438,loss,subtype,cytoskeletal,synaptopodin,podocytes,GFB8438,kidney,disease,acetate,GFB-8438
CBNumber:
CB25855430
Molecular Formula:
C16H14ClF3N4O2
Molecular Weight:
386.76
MDL Number:
MFCD32671553
MOL File:
2304549-73-1.mol
Last updated:2025-12-03 09:04:23
Product description Number Pack Size Price
GFB-8438 98.07% CS-0109395 5mg $280
GFB-8438 98.07% CS-0109395 10mg $480
GFB-8438 98.07% CS-0109395 50mg $1400
GFB-8438 98.07% CS-0109395 100mg $2250
GFB-8438 012754 001 $650
Request For Quotation

GFB-8438 Properties

Density 1.52±0.1 g/cm3(Predicted)
solubility DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
form Solid
pka 9.09±0.60(Predicted)
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

GFB-8438 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0109395 GFB-8438 98.07% 2304549-73-1 5mg $280 2021-12-16 Buy
ChemScene CS-0109395 GFB-8438 98.07% 2304549-73-1 10mg $480 2021-12-16 Buy
ChemScene CS-0109395 GFB-8438 98.07% 2304549-73-1 50mg $1400 2021-12-16 Buy
ChemScene CS-0109395 GFB-8438 98.07% 2304549-73-1 100mg $2250 2021-12-16 Buy
DC Chemicals 012754 GFB-8438 2304549-73-1 001 $650 2021-12-16 Buy
Product number Packaging Price Buy
CS-0109395 5mg $280 Buy
CS-0109395 10mg $480 Buy
CS-0109395 50mg $1400 Buy
CS-0109395 100mg $2250 Buy
012754 001 $650 Buy

GFB-8438 Chemical Properties,Uses,Production

Uses

GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].

in vivo

GFB-8438 (30 mg/kg; s.c.; daily for 3 weeks) is efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of focal segmental glomerulosclerosis (FSGS), significantly reducing both total protein and albumin concentrations in urine[1].
GFB-8438 (1 mg/kg; i.v.) treatment shows the?Cl,?VSS,?and ?t1/2?were?31?mL/min/kg,?1.17?L/kg,?and?0.5 hours, respectively[1].

Animal Model:Sprague Dawley rats (DOCA-salt rat model of FSGS)[1]
Dosage:30 mg/kg
Administration:s.c.; daily for 3 weeks
Result:Significant reduction in urine protein concentrations.
Animal Model:6-8 weeks old male SD rats[1]
Dosage:1 mg/kg
Administration:i.v. (Pharmacokinetic?Analysis)
Result:The?Cl,?Vss,??and t1/2?were?31?mL/min/kg,?1.17?L/kg,?and?0.5 hours, respectively.

IC 50

hTRPC5: 0.18 μM (IC50); hTRPC4: 0.29 μM (IC50); rTRPC5: 0.18 μM (IC50)

References

[1] Yu M, et al.Discovery?of a?Potent?and?Selective?TRPC5?Inhibitor,?Efficacious?in a?Focal?Segmental?Glomerulosclerosis?Model.ACS Med Chem Lett.?2019 Oct 22;10(11):1579-1585. DOI:10.1021/acsmedchemlett.9b00430

GFB-8438 Preparation Products And Raw materials

Raw materials

Preparation Products

GFB-8438 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4768 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 8011 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55

View Lastest Price from GFB-8438 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GFB-8438 pictures 2025-12-05 GFB-8438
2304549-73-1
 US $48.00-119.00 / mg 99.58% 10g TargetMol Chemicals Inc.
GFB-8438 pictures 2025-12-05 GFB-8438
2304549-73-1
 US $48.00-119.00 / mg 99.58% 10g TargetMol Chemicals Inc.
  • GFB-8438 pictures
  • GFB-8438
    2304549-73-1
  • US $48.00-119.00 / mg
  • 99.58%
  • TargetMol Chemicals Inc.
  • GFB-8438 pictures
  • GFB-8438
    2304549-73-1
  • US $48.00-119.00 / mg
  • 99.58%
  • TargetMol Chemicals Inc.

GFB-8438 Spectrum

GFB-8438(2304549-73-1)1HNMR
GFB-8438 3(2H)-Pyridazinone, 4-chloro-5-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]-1-piperazinyl]- 4-Chloro-5-[3-oxo-4-(2-trifluoromethyl-benzyl)-piperazin-1-yl]-2H-pyridazin-3-one 4-chloro-5-(3-oxo-4-(2-(trifluoromethyl)benzyl)piperazin-1-yl)pyridazin-3(2H)-one mouse,selective,Transient receptor potential channels,Inhibitor,inhibit,remodeling,TRP Channel,deoxycorticosterone,GFB 8438,loss,subtype,cytoskeletal,synaptopodin,podocytes,GFB8438,kidney,disease,acetate,GFB-8438 GFB-8438, 10 mM in DMSO GFB-8438 ，S0750 2304549-73-1