INTERFERON GAMMA 1 B
- CAS No.
- 98059-61-1
- Chemical Name:
- INTERFERON GAMMA 1 B
- Synonyms
- IFN-y;Interferon γ-1b;INTERFERON GAMMA 1 B;Interferon gamma-1b CRS;IFNγ, Human (CHO-expressed);Interferon γ-1b validation solution;Interferon γ-1b for system suitability;Interferon gamma-1b for system suitability CRS
- CBNumber:
- CB2587789
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
FDA UNII | 21K6M2I7AG |
---|---|
NCI Drug Dictionary | interferon gamma-1b |
INTERFERON GAMMA 1 B price More Price(1)
INTERFERON GAMMA 1 B Chemical Properties,Uses,Production
Description
Interferon gamma-lb, a recombinant DNA product, has orphan drug status for the treatment of chronic granulomatous disease. It is also under investigation as a treatment for trauma-related infections and atopic dermatitis.
Originator
Genentech (U.S.A.)
Uses
Antineoplastic; biological response modifier; immunoregulator.
brand name
Actimmune
General Description
Interferon gamma-1b, Actimmune, is a recombinant proteinexpressed in E. coli. IFN-γ is the cytokine that is secreted byhuman T lymphocytes and NK cells. It is a single-chain glycoproteincomposed of 140 amino acids. The crystal structure of the protein reveals several helical segments arranged toapproximate a toric shape.
Interferon gamma-1b is indicated for reducing the frequencyand severity of serious infections associated withchronic granulomatous disease, an inherited disorder characterizedby deficient phagocyte oxidase activity. In this disease,macrophages try to respond to invading organisms butlack the key oxidative enzymes to dispose of them. To compensate,additional macrophages are recruited into the infectedregion and form a granulomatous structure around thesite. IFN-γ can stimulate the oxidative burst in macrophagesand may reverse the situation.
Interferon gamma-1b is supplied as a solution in sterilewater for injection. The solution must be stored at 2°C to8°C, without freezing. The product cannot tolerate morethan 12 hours at room temperature.
Clinical Use
Adjunct to antibiotics to reduce the frequency of serious infections in patients with chronic granulomatous disease
Drug interactions
Potentially hazardous interactions with other drugs
Avoid with vaccines.
Metabolism
The metabolism of cloned interferons falls within the
natural handling of proteins. Interferon gamma-1b
was not detected in the urine of healthy male subjects
following administration via IV, IM or SC routes. In vitro
hepatic and renal perfusion studies demonstrate that
the liver and kidneys are capable of clearing interferon
gamma-1b from perfusate.
Interferon is metabolised primarily in the kidney. It is
excreted in the urine, but is reabsorbed by the tubules
where it undergoes lysosomal degradation.
INTERFERON GAMMA 1 B Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10787 | 58 |
Jiangxi ravel Biotechnology Co.,Ltd | 400-880-2824 18107960669 | bd@ruiweier.cn | China | 1013 | 58 |
Abmole Bioscience Inc. | 021-50967598 02150967598 | sales@abmole.cn | China | 4495 | 58 |
Jiangxi ravel Biotechnology Co.,Ltd | 185-0276-2003 18502762003; | 435918333@qq.com | China | 2243 | 58 |
Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-021-59178156 17002132182 | 3146474380@qq.com | China | 11609 | 58 |
Hubei Kailong Biotechnology Co.,Ltd. | 19526384105 | 3671394075@qq.com | China | 2476 | 58 |
View Lastest Price from INTERFERON GAMMA 1 B manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-01-06 | INTERFERON GAMMA 1 B
98059-61-1
|
US $2.20 / KG | 1KG | 98% | 1KG/10KG/100KG | Career Henan Chemica Co |
- INTERFERON GAMMA 1 B
98059-61-1
- US $2.20 / KG
- 98%
- Career Henan Chemica Co