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(R)-Dimethindene Maleate
- CAS No.
- 136152-64-2
- Chemical Name:
- (R)-Dimethindene Maleate
- Synonyms
- (R)-Dimethindene Maleate
- CBNumber:
- CB29385065
- Molecular Formula:
- C24H28N2O4
- Molecular Weight:
- 408.5
- MDL Number:
- MOL File:
- 136152-64-2.mol
Last updated:2025-04-17 18:22:24
(R)-Dimethindene Maleate Chemical Properties,Uses,Production
Uses
(R)-Dimethindene Maleate is a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist.
in vivo
(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED50 of 2.73 mg/kg in pigs[1].
| Animal Model: | Male guinea-pigs[1] |
| Dosage: | 10 mL/kg |
| Administration: | Oral gavage, once |
| Result: | The ED50-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED50-value was found to be >31.6mg/kg. The oral LD50-values was found to be 988 mg/kg. |
IC 50
H1 Receptor: 7.7 (pA2)
(R)-Dimethindene Maleate Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-Dimethindene Maleate Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3011 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Supplier | Advantage |
|---|---|
| Guangzhou Younan Technology Co., Ltd | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
(R)-Dimethindene Maleate
136152-64-2
