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ChemicalBook >> CAS DataBase List >>2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)-

2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)-

2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- Structure
2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- structure
CAS No.
2631659-57-7
Chemical Name:
2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)-
Synonyms
C3N-Dbn-Trp2;2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)-
CBNumber:
CB314685681
Molecular Formula:
C36H32N4O2
Molecular Weight:
552.67
MDL Number:
MOL File:
2631659-57-7.mol
Last updated:2025-04-18 09:52:03
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2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- Properties

Boiling point 839.8±65.0 °C(predicted)
Density 1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 13.48±0.60(predicted)

2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- Chemical Properties,Uses,Production

Uses

C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 (HY-D0816) efflux in cells HEK293T and HCT-15 with IC50 of 5.9 μM and 2.2 μM. C3N-Dbn-Trp2 inhibits the Doxorubicin (HY-15142A) efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells[1].

References

[1] Koh JYP, et al., Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors. Commun Chem. 2024 Jul 13;7(1):158. DOI:10.1038/s42004-024-01225-z

2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- Suppliers

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TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
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TargetMol Chemicals Inc. 58
2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- C3N-Dbn-Trp2 2631659-57-7