Epiquinine

Description

This alkaloid, which is stereoisomeric with epiquinidine (q.v.) is also found in 'quinoidine', the mixture of bases remaining after the removal of the major alkaloids of Cinchona barks. It is also an oil having [α]²²_D + 43.3° (c 0.95, EtOH) yielding a dihydrochloride, m.p. 196°C (dec.); [α]²¹_D + 33.3° (c 0.796, EtOH), a hydrobromide, m.p. 71-7°C; [α]²⁰_D + 32.9° (H20) and the dibenzoyl (+)-tartrate, m.p. 159°C (dec.); [α]¹⁹_D - 22.4° (c 0.8044, EtOH). On catalytic hydrogenation in the presence of Pd it forms the dihydro derivative which is an oil having [α]²²_D + 31.1° (c 0.9342, EtOH).

References

Thron, Dirscherl., Annalen, 521, 48 (1935)

Raw materials

Preparation Products