Description
Histone H3 is a nuclear protein and component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs). Metazoans have three histone variants: canonical histone H3.1, DNA replication-independent histone H3.3, and the centromeric variant CENP-A.2 Histone H3.3 is incorporated into chromatin in a DNA replication-independent manner at sites of active transcription.2,3,4 A missense mutation replacing guanine with adenine in H3F3A, the gene encoding histone H3.3, leads to a glycine-to-valine substitution, histone H3.3G34V, which is associated with glioblastoma multiforme in children and young adults.5 Cayman's Histone H3.3G34V Rabbit Monoclonal Antibody (Clone RM307) - Biotinylated can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
